Depression, anxiety and perceived stress in women with and without PCOS: A community-based study

Anna L. Damone, Anju E. Joham, Deborah Loxton, Arul Earnest, Helena J. Teede, Lisa J. Moran

Research output: Contribution to journalArticleResearchpeer-review

Abstract

BackgroundPolycystic ovary syndrome (PCOS) is associated with increased psychological distress in clinical populations. We aimed to assess depression, anxiety and perceived stress in women with and without PCOS in a large community-based sample and investigate the role of stress in contributing to and mediating the relationship between PCOS, depression and anxiety.MethodsA cross-sectional analysis was performed from the Australian Longitudinal Study of Women's Health (ALWSH) comparing women with (n = 478) or without (n = 8134) a self-reported diagnosis of PCOS. Main outcome measures were depression, anxiety and perceived stress measured using validated scales. The χ2 and t tests were used to assess differences between groups. Univariable and multivariable regression were performed to determine factors contributing to each outcome.ResultsWomen reporting PCOS, compared with women not reporting PCOS, reported higher prevalence of depression (27.3% v. 18.8%), anxiety symptoms (50% v. 39.2%) and greater score for perceived stress (1.01 ± 0.03 v. 0.88 ± 0.01). After adjusting for body mass index, infertility and socio-demographic factors, women with PCOS were still more likely to be depressed, anxious and to have a higher level of perceived stress. There was a high-level mediation effect of stress between PCOS and both depression and anxiety.ConclusionCompared with women not reporting PCOS, women reporting PCOS have increased depression, anxiety and perceived stress. Stress may play a role in the association between PCOS, depression and anxiety. Further studies should consider assessment and management of stress in PCOS as it may be relevant for understanding the aetiology and treatment of psychological distress.

Original languageEnglish
Pages (from-to)1510-1520
Number of pages11
JournalPsychological Medicine
Volume49
Issue number9
DOIs
Publication statusPublished - 1 Jul 2019

Keywords

  • Anxiety
  • depression
  • PCOS
  • stress

Cite this

@article{82da6ddab4b044e6ba9ada5da7402020,
title = "Depression, anxiety and perceived stress in women with and without PCOS: A community-based study",
abstract = "BackgroundPolycystic ovary syndrome (PCOS) is associated with increased psychological distress in clinical populations. We aimed to assess depression, anxiety and perceived stress in women with and without PCOS in a large community-based sample and investigate the role of stress in contributing to and mediating the relationship between PCOS, depression and anxiety.MethodsA cross-sectional analysis was performed from the Australian Longitudinal Study of Women's Health (ALWSH) comparing women with (n = 478) or without (n = 8134) a self-reported diagnosis of PCOS. Main outcome measures were depression, anxiety and perceived stress measured using validated scales. The {\"I}‡2 and t tests were used to assess differences between groups. Univariable and multivariable regression were performed to determine factors contributing to each outcome.ResultsWomen reporting PCOS, compared with women not reporting PCOS, reported higher prevalence of depression (27.3{\%} v. 18.8{\%}), anxiety symptoms (50{\%} v. 39.2{\%}) and greater score for perceived stress (1.01 ± 0.03 v. 0.88 ± 0.01). After adjusting for body mass index, infertility and socio-demographic factors, women with PCOS were still more likely to be depressed, anxious and to have a higher level of perceived stress. There was a high-level mediation effect of stress between PCOS and both depression and anxiety.ConclusionCompared with women not reporting PCOS, women reporting PCOS have increased depression, anxiety and perceived stress. Stress may play a role in the association between PCOS, depression and anxiety. Further studies should consider assessment and management of stress in PCOS as it may be relevant for understanding the aetiology and treatment of psychological distress.",
keywords = "Anxiety, depression, PCOS, stress",
author = "Damone, {Anna L.} and Joham, {Anju E.} and Deborah Loxton and Arul Earnest and Teede, {Helena J.} and Moran, {Lisa J.}",
year = "2019",
month = "7",
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doi = "10.1017/S0033291718002076",
language = "English",
volume = "49",
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Depression, anxiety and perceived stress in women with and without PCOS : A community-based study. / Damone, Anna L.; Joham, Anju E.; Loxton, Deborah; Earnest, Arul; Teede, Helena J.; Moran, Lisa J.

In: Psychological Medicine, Vol. 49, No. 9, 01.07.2019, p. 1510-1520.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Depression, anxiety and perceived stress in women with and without PCOS

T2 - A community-based study

AU - Damone, Anna L.

AU - Joham, Anju E.

AU - Loxton, Deborah

AU - Earnest, Arul

AU - Teede, Helena J.

AU - Moran, Lisa J.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - BackgroundPolycystic ovary syndrome (PCOS) is associated with increased psychological distress in clinical populations. We aimed to assess depression, anxiety and perceived stress in women with and without PCOS in a large community-based sample and investigate the role of stress in contributing to and mediating the relationship between PCOS, depression and anxiety.MethodsA cross-sectional analysis was performed from the Australian Longitudinal Study of Women's Health (ALWSH) comparing women with (n = 478) or without (n = 8134) a self-reported diagnosis of PCOS. Main outcome measures were depression, anxiety and perceived stress measured using validated scales. The χ2 and t tests were used to assess differences between groups. Univariable and multivariable regression were performed to determine factors contributing to each outcome.ResultsWomen reporting PCOS, compared with women not reporting PCOS, reported higher prevalence of depression (27.3% v. 18.8%), anxiety symptoms (50% v. 39.2%) and greater score for perceived stress (1.01 ± 0.03 v. 0.88 ± 0.01). After adjusting for body mass index, infertility and socio-demographic factors, women with PCOS were still more likely to be depressed, anxious and to have a higher level of perceived stress. There was a high-level mediation effect of stress between PCOS and both depression and anxiety.ConclusionCompared with women not reporting PCOS, women reporting PCOS have increased depression, anxiety and perceived stress. Stress may play a role in the association between PCOS, depression and anxiety. Further studies should consider assessment and management of stress in PCOS as it may be relevant for understanding the aetiology and treatment of psychological distress.

AB - BackgroundPolycystic ovary syndrome (PCOS) is associated with increased psychological distress in clinical populations. We aimed to assess depression, anxiety and perceived stress in women with and without PCOS in a large community-based sample and investigate the role of stress in contributing to and mediating the relationship between PCOS, depression and anxiety.MethodsA cross-sectional analysis was performed from the Australian Longitudinal Study of Women's Health (ALWSH) comparing women with (n = 478) or without (n = 8134) a self-reported diagnosis of PCOS. Main outcome measures were depression, anxiety and perceived stress measured using validated scales. The χ2 and t tests were used to assess differences between groups. Univariable and multivariable regression were performed to determine factors contributing to each outcome.ResultsWomen reporting PCOS, compared with women not reporting PCOS, reported higher prevalence of depression (27.3% v. 18.8%), anxiety symptoms (50% v. 39.2%) and greater score for perceived stress (1.01 ± 0.03 v. 0.88 ± 0.01). After adjusting for body mass index, infertility and socio-demographic factors, women with PCOS were still more likely to be depressed, anxious and to have a higher level of perceived stress. There was a high-level mediation effect of stress between PCOS and both depression and anxiety.ConclusionCompared with women not reporting PCOS, women reporting PCOS have increased depression, anxiety and perceived stress. Stress may play a role in the association between PCOS, depression and anxiety. Further studies should consider assessment and management of stress in PCOS as it may be relevant for understanding the aetiology and treatment of psychological distress.

KW - Anxiety

KW - depression

KW - PCOS

KW - stress

UR - http://www.scopus.com/inward/record.url?scp=85052657280&partnerID=8YFLogxK

U2 - 10.1017/S0033291718002076

DO - 10.1017/S0033291718002076

M3 - Article

VL - 49

SP - 1510

EP - 1520

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

IS - 9

ER -