Dengue virus infections and maternal antibody decay in a prospective birth cohort study of vietnamese infants

Tran Nguyen Bich Chau, Nguyen Trong Hieu, Katherine L. Anders, Marcel Wolbers, Le Bich Lien, Lu Thi Minh Hieu, Tran Tinh M Hien, Nguyen Thanh Hung, Jeremy Farrar, Stephen S. Whitehead, Cameron P. Simmons

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Abstract

Dengue hemorrhagic fever can occur in primary dengue virus (DENV) infection of infants. The decay of maternally derived DENV immunoglobulin (Ig) G and the incidence of DENV infection were determined in a prospectively studied cohort of 1244 Vietnamese infants. Higher concentrations of total IgG and DENVreactive IgG were found in cord plasma relative to maternal plasma. Maternally derived DENV-neutralizing and E protein-reactive IgG titers declined to below measurable levels in >90% of infants by 6 months of age. In contrast, IgG reactive with whole DENV virions persisted until 12 months of age in 20% of infants. Serological surveillance identified 10 infants with asymptomatic DENV infection for an incidence of 1.7 cases per 100 person-years. DENV-neutralizing antibodies remained measurable for ≥1 year after infection. These results suggest that whereas DENV infection in infants is frequently subclinical, there is a window between 4 and 12 months of age where virion-binding but nonneutralizing IgG could facilitate antibody-dependent enhancement.

Original languageEnglish
Pages (from-to)1893-1900
Number of pages8
JournalJournal of Infectious Diseases
Volume200
Issue number12
DOIs
Publication statusPublished - Dec 2009
Externally publishedYes

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