Dendritic Cells and Their Roles in Anti-Tumour Immunity

Ee Shan Pang, Christophe Macri, Tim Patton, Mariam Bafit, Meredith O'Keeffe

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Dendritic cells are rare cells found in blood and throughout all organs of the body as resident or migrating cell populations. Dendritic cells sense danger signals of pathogens and host cell stress through pattern receptors expressed on the cell surface and within organelles of the cell. Ligation of these receptors leads to activation and production of many different chemokines, cytokines and interferons. Key to the function of dendritic cells is their potent capacity to present antigen and activate naïve T cells. These qualities, potent antigen presentation and cytokine production together allow the dendritic cells to be at the forefront of danger responses, linking innate and adaptive immunity. Research over the last 20 years has clarified a role of dendritic cells in anti-tumour responses, and their location within the tumour environment is clear, with both deleterious and beneficial correlations, depending on the subset and tumour type. Harnessing the qualities of dendritic cells to increase anti-tumour immunity is the ultimate goal, although this will require extensive knowledge of different dendritic cell subsets and their regulation through immune checkpoints.
Original languageEnglish
Title of host publicationCurrent Cancer Treatment
EditorsMirjana Rajer, Eva Segelov
Place of PublicationLondon UK
PublisherIntechOpen Limited
Chapter4
Number of pages27
ISBN (Electronic)9781838809980
ISBN (Print)9781789859683, 9781789859676
DOIs
Publication statusPublished - 2020

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