Dendritic cell vaccination

Owen Proudfoot, Dodie Pouniotis, Kuo-Ching Sheng, Bruce E Loveland, Geoffrey A Pietersz

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)


There has been a surge of interest in the use of dendritic cell (DC) vaccination as cellular immunotherapy for numerous cancers. Despite some encouraging results, this therapeutic modality is far from being considered as a therapy for cancer. This review will first discuss preclinical DC vaccination in murine models of cancer, with an emphasis on comparative studies investigating different methods of antigen priming. We will then comment on the various murine DC subsets and how these relate to human DC preparations used for clinical studies. Finally, the methodology used to generate human DCs and some recent clinical trials in several cancers are reviewed.
Original languageEnglish
Pages (from-to)617 - 633
Number of pages17
JournalExpert Review of Vaccines
Issue number4
Publication statusPublished - 2007

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