Dendritic cell subsets and immune regulation

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Dendritic cells (DC) are efficient antigen presenting cells. They represent a dynamic network in the immune system and can collect and process antigens for presentation to T cells. Although all can present antigens, DC differ in the additional regulatory signals they transmit to direct T cells to different types of immune responses or to tolerance. Many DC subtypes are present in non-lymphoid and lymphoid tissues and their development and function is modulated by exogenous factors such as cytokines and microbial products. Many studies on DC biology in recent years have revealed their important roles in modulating immune responses, which provide great potential for designing more effective vaccines and new therapies for the treatment of cancer and other immune-related diseases through targeting the DC.

Original languageEnglish
Title of host publicationInnate Immune Regulation and Cancer Immunotherapy
PublisherSpringer
Pages89-119
Number of pages31
ISBN (Electronic)9781441999146
ISBN (Print)9781441999139
DOIs
Publication statusPublished - 1 Jan 2012
Externally publishedYes

Cite this

O'Keeffe, M., Lahoud, M. H., Caminschi, I., & Wu, L. (2012). Dendritic cell subsets and immune regulation. In Innate Immune Regulation and Cancer Immunotherapy (pp. 89-119). Springer. https://doi.org/10.1007/978-1-4419-9914-6_7