Dendritic cell lectin-targeting sentinel-like unimolecular glycoconjugates to release an anti-HIV drug

Qiang Zhang; Lu Su; Jennifer Collins; Guosong Chen; Russell Wallis; Daniel A. Mitchell; David M. Haddleton; C. Remzi Becer

doi:10.1021/ja4131565

Dendritic cell lectin-targeting sentinel-like unimolecular glycoconjugates to release an anti-HIV drug

Qiang Zhang
, Lu Su
, Jennifer Collins
, Guosong Chen
, Russell Wallis
, Daniel A. Mitchell
, David M. Haddleton
, C. Remzi Becer

Research output: Contribution to journal › Article › Research › peer-review

148 Citations (Scopus)

Abstract

A series of cyclodextrin-based glycoconjugates, including glycoclusters and star glycopolymers, were synthesized via combination of CuAAC Huisgen coupling and copper-mediated living radical polymerization. These glycoconjugates showed high affinity binding to the human transmembrane lectin DC-SIGN and act as inhibitors to prevent the binding of HIV envelope protein gp120 to DC-SIGN at nanomolar concentrations. The star block glycopolymers showed high loading capacity of hydrophobic anticancer and anti-HIV drugs, indicating promising applications in HIV-therapeutic and smart drug delivery.

Original language	English
Pages (from-to)	4325-4332
Number of pages	8
Journal	Journal of the American Chemical Society
Volume	136
Issue number	11
DOIs	https://doi.org/10.1021/ja4131565
Publication status	Published - 19 Mar 2014
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1021/ja4131565

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title = "Dendritic cell lectin-targeting sentinel-like unimolecular glycoconjugates to release an anti-HIV drug",

abstract = "A series of cyclodextrin-based glycoconjugates, including glycoclusters and star glycopolymers, were synthesized via combination of CuAAC Huisgen coupling and copper-mediated living radical polymerization. These glycoconjugates showed high affinity binding to the human transmembrane lectin DC-SIGN and act as inhibitors to prevent the binding of HIV envelope protein gp120 to DC-SIGN at nanomolar concentrations. The star block glycopolymers showed high loading capacity of hydrophobic anticancer and anti-HIV drugs, indicating promising applications in HIV-therapeutic and smart drug delivery.",

author = "Qiang Zhang and Lu Su and Jennifer Collins and Guosong Chen and Russell Wallis and Mitchell, \{Daniel A.\} and Haddleton, \{David M.\} and Becer, \{C. Remzi\}",

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doi = "10.1021/ja4131565",

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AU - Zhang, Qiang

AU - Su, Lu

AU - Collins, Jennifer

AU - Chen, Guosong

AU - Wallis, Russell

AU - Mitchell, Daniel A.

AU - Haddleton, David M.

AU - Becer, C. Remzi

PY - 2014/3/19

Y1 - 2014/3/19

N2 - A series of cyclodextrin-based glycoconjugates, including glycoclusters and star glycopolymers, were synthesized via combination of CuAAC Huisgen coupling and copper-mediated living radical polymerization. These glycoconjugates showed high affinity binding to the human transmembrane lectin DC-SIGN and act as inhibitors to prevent the binding of HIV envelope protein gp120 to DC-SIGN at nanomolar concentrations. The star block glycopolymers showed high loading capacity of hydrophobic anticancer and anti-HIV drugs, indicating promising applications in HIV-therapeutic and smart drug delivery.

AB - A series of cyclodextrin-based glycoconjugates, including glycoclusters and star glycopolymers, were synthesized via combination of CuAAC Huisgen coupling and copper-mediated living radical polymerization. These glycoconjugates showed high affinity binding to the human transmembrane lectin DC-SIGN and act as inhibitors to prevent the binding of HIV envelope protein gp120 to DC-SIGN at nanomolar concentrations. The star block glycopolymers showed high loading capacity of hydrophobic anticancer and anti-HIV drugs, indicating promising applications in HIV-therapeutic and smart drug delivery.

UR - https://www.scopus.com/pages/publications/84896535481

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JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 11

ER -

Dendritic cell lectin-targeting sentinel-like unimolecular glycoconjugates to release an anti-HIV drug

Abstract

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