Dendrimer-fullerenol soft-condensed nanoassembly

Priyanka Bhattacharya, Seung Ha Kim, Pengyu Chen, Ran Chen, Anne M. Spuches, Jared M. Brown, Monica H. Lamm, Pu Chun Ke

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17 Citations (Scopus)


Nanoscale assembly is an area of research that has vast implications for molecular design, sensing, nanofabrication, supramolecular chemistry, catalysis, and environmental remediation. Here we show that poly(amidoamine) (PAMAM) dendrimers of both generations 1 (G1) and 4 (G4) can host 1 fullerenol per 2 dendrimer primary amines as evidenced by isothermal titration calorimetry, dynamic light scattering, and spectrofluorometry. Thermodynamically, the interactions were similarly spontaneous between both generations of dendrimers and fullerenols, however, G4 formed stronger complexes with fullerenols resulting from their higher surface charge density and more internal voids, as demonstrated by spectrofluorometry. In addition to hydrogen bonding that existed between the dendrimer primary amines and the fullerenol oxygens, hydrophobic and electrostatic interactions also contributed to complex formation and dynamics. Such a hybrid of soft and condensed nanoassembly may have implications for environmental remediation of discharged nanomaterials and entail new applications in drug delivery.

Original languageEnglish
Pages (from-to)15775-15781
Number of pages7
JournalJournal of Physical Chemistry C
Issue number29
Publication statusPublished - 26 Jul 2012
Externally publishedYes

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