Demonstration of a S-methyl metabolite of captopril in patients undergoing chronic captopril therapy

O. H. Drummer, B. Jarrott, W. J. Louis

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Abstract

The formation of the S-methyl metabolite of captopril has been demonstrated for the first time in the urine of five patients receiving chronic captopril therapy. Patients were studied following a 100 mg oral dose or captopril. Excretion values for S-methylcaptopril were 0.66 mg and 0.31 mg at 0-3 h and 3-6 h postdose. Captopril excretion was at these two collections 15.5 mg and 2.3 mg, respectively.

Original languageEnglish
Article numberSuppl. 7
Pages (from-to)81-86
Number of pages6
JournalClinical and Experimental Pharmacology and Physiology
Volume9
Issue numberSuppl. 7
Publication statusPublished - 1982
Externally publishedYes

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