Projects per year
Abstract
Delta (δ-) and epsilon (ε-) tubulin are lesser-known cousins of alpha (α-) and beta (β-) tubulin. They are likely to regulate centriole function in a broad range of species; however, their in vivo role and mechanism of action in mammals remain mysterious. In unicellular species and mammalian cell lines, mutations in δ- and ε-tubulin cause centriole destabilization and atypical mitosis and, in the most severe cases, cell death. Beyond the centriole, δ- and ε-tubulin localize to the manchette during murine spermatogenesis and interact with katanin-like 2 (KATNAL2), a protein with microtubule (MT)-severing properties, indicative of novel non-centriolar functions. Herein we summarize the current knowledge surrounding δ- and ε-tubulin, identify pathways for future research, and highlight how and why spermatogenesis and embryogenesis are ideal systems to define δ- and ε-tubulin function in vivo.
Original language | English |
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Pages (from-to) | 774-787 |
Number of pages | 14 |
Journal | Trends in Cell Biology |
Volume | 31 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1 Sep 2021 |
Keywords
- basal body
- centriole
- delta tubulin
- embryogenesis
- epsilon tubulin
- spermatogenesis
Projects
- 2 Curtailed
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Building the mid-piece of the sperm tail
O'Bryan, M. & Dunleavy, J.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 19/10/20
Project: Research
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