Delivery of siRNA Using Cationic Liposomes Incorporating Stearic Acid-modified Octa-Arginine

Dongsheng Yang, Yuhuan Li, Yuhang Qi, Yongzhen Chen, Xuewei Yang, Yujing Li, Songcai Liu, Robert J. Lee

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Cationic liposomes incorporating stearic acidmodified octa-arginine (StA-R8) were evaluated for survivin small interfering RNA (siRNA) delivery. StA-R8 was synthesized and incorporated into liposomes. The composition of liposomes was optimized. Physicochemical properties, cytotoxicity, cellular uptake and gene silencing activity of the liposomes complexed to survivin siRNA were investigated. The results showed that StA-R8-containing liposomes had reduced cytotoxicity and improved delivery efficiency of siRNA into cancer cells compared with StA-R8 by itself.

Original languageEnglish
Pages (from-to)3271-3276
Number of pages6
JournalAnticancer Research
Volume36
Issue number7
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Cancer
  • Cationic liposomes
  • Cell-penetrating peptide
  • Octa-arginine
  • Survivin

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