Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: A predominant role of anti-inflammation

Xiao-Ming Gao, Yang Liu, David White, Yi-Dan Su, Brian Drew, Clinton Bruce, Helen Kiriazis, Qi Xu, Nicole Jennings, Alex Bobik, Mark Febbraio, Bronwyn Kingwell, Richard Bucala, Gunter Fingerle-Rowson, Anthony M Dart, Eric Morand, Xiao-Jun Du

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87 Citations (Scopus)

Abstract

Inflammation plays an important role in mediating and exacerbating myocardial ischemia-reperfusion (I/R) injury. Macrophage migration inhibitory factor (MIF), a pleiotropic cytokine, facilitates inflammation and modulates metabolism. However, the role of MIF in mediating local inflammation subsequent to ischemic myocardial injury has not been established. We hypothesized that genetic deletion of MIF protects the heart against severe I/R injury by suppressing inflammation and/or modulating energy metabolism. We showed in the mouse I/R model that duration of both ischemia and reperfusion is a determinant for the degree of regional inflammation and tissue damage. Following a prolonged cardiac I/R (60min/24h) MIF KO mice had a significant reduction in both infarct size (26A?3 vs. 45A?4 , P
Original languageEnglish
Pages (from-to)991 - 999
Number of pages9
JournalJournal of Molecular and Cellular Cardiology
Volume50
Issue number6
DOIs
Publication statusPublished - 2011

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