TY - JOUR
T1 - Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: A predominant role of anti-inflammation
AU - Gao, Xiao-Ming
AU - Liu, Yang
AU - White, David
AU - Su, Yi-Dan
AU - Drew, Brian
AU - Bruce, Clinton
AU - Kiriazis, Helen
AU - Xu, Qi
AU - Jennings, Nicole
AU - Bobik, Alex
AU - Febbraio, Mark
AU - Kingwell, Bronwyn
AU - Bucala, Richard
AU - Fingerle-Rowson, Gunter
AU - Dart, Anthony M
AU - Morand, Eric
AU - Du, Xiao-Jun
PY - 2011
Y1 - 2011
N2 - Inflammation plays an important role in mediating and exacerbating myocardial ischemia-reperfusion (I/R) injury. Macrophage migration inhibitory factor (MIF), a pleiotropic cytokine, facilitates inflammation and modulates metabolism. However, the role of MIF in mediating local inflammation subsequent to ischemic myocardial injury has not been established. We hypothesized that genetic deletion of MIF protects the heart against severe I/R injury by suppressing inflammation and/or modulating energy metabolism. We showed in the mouse I/R model that duration of both ischemia and reperfusion is a determinant for the degree of regional inflammation and tissue damage. Following a prolonged cardiac I/R (60min/24h) MIF KO mice had a significant reduction in both infarct size (26A?3 vs. 45A?4 , P
AB - Inflammation plays an important role in mediating and exacerbating myocardial ischemia-reperfusion (I/R) injury. Macrophage migration inhibitory factor (MIF), a pleiotropic cytokine, facilitates inflammation and modulates metabolism. However, the role of MIF in mediating local inflammation subsequent to ischemic myocardial injury has not been established. We hypothesized that genetic deletion of MIF protects the heart against severe I/R injury by suppressing inflammation and/or modulating energy metabolism. We showed in the mouse I/R model that duration of both ischemia and reperfusion is a determinant for the degree of regional inflammation and tissue damage. Following a prolonged cardiac I/R (60min/24h) MIF KO mice had a significant reduction in both infarct size (26A?3 vs. 45A?4 , P
UR - http://www.ncbi.nlm.nih.gov/pubmed/21215754
U2 - 10.1016/j.yjmcc.2010.12.022
DO - 10.1016/j.yjmcc.2010.12.022
M3 - Article
SN - 0022-2828
VL - 50
SP - 991
EP - 999
JO - Journal of Molecular and Cellular Cardiology
JF - Journal of Molecular and Cellular Cardiology
IS - 6
ER -