Degradable graft copolymers by ring-opening and reverse addition-fragmentation chain transfer polymerization

Rebecca J. Williams; Rachel K. O'Reilly; Andrew P. Dove

doi:10.1039/c2py20213a

Degradable graft copolymers by ring-opening and reverse addition-fragmentation chain transfer polymerization

Rebecca J. Williams, Rachel K. O'Reilly, Andrew P. Dove

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Abstract

The synthesis and controlled ring-opening polymerization (ROP) of a six membered cyclic carbonate monomer with pendant reversible addition-fragmentation chain transfer (RAFT) functionality is reported. The growth of fast propagating monomers (methyl acrylate, tetrahydropyran acrylate and N-isopropylacrylamide) from the obtained RAFT-functional poly(carbonate)s resulted in the formation of well-defined graft copolymers with a biodegradable backbone, when grafting was terminated at low monomer conversions (ca. 30%). Direct dissolution of the thermally responsive poly(carbonate)-graft-PNiPAm copolymer yielded spherical micelles as confirmed by DLS and TEM analysis.

Original language	English
Pages (from-to)	2156-2164
Number of pages	9
Journal	Polymer Chemistry
Volume	3
Issue number	8
DOIs	https://doi.org/10.1039/c2py20213a
Publication status	Published - Aug 2012
Externally published	Yes

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title = "Degradable graft copolymers by ring-opening and reverse addition-fragmentation chain transfer polymerization",

abstract = "The synthesis and controlled ring-opening polymerization (ROP) of a six membered cyclic carbonate monomer with pendant reversible addition-fragmentation chain transfer (RAFT) functionality is reported. The growth of fast propagating monomers (methyl acrylate, tetrahydropyran acrylate and N-isopropylacrylamide) from the obtained RAFT-functional poly(carbonate)s resulted in the formation of well-defined graft copolymers with a biodegradable backbone, when grafting was terminated at low monomer conversions (ca. 30\%). Direct dissolution of the thermally responsive poly(carbonate)-graft-PNiPAm copolymer yielded spherical micelles as confirmed by DLS and TEM analysis.",

author = "Williams, \{Rebecca J.\} and O'Reilly, \{Rachel K.\} and Dove, \{Andrew P.\}",

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language = "English",

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T1 - Degradable graft copolymers by ring-opening and reverse addition-fragmentation chain transfer polymerization

AU - Williams, Rebecca J.

AU - O'Reilly, Rachel K.

AU - Dove, Andrew P.

PY - 2012/8

Y1 - 2012/8

N2 - The synthesis and controlled ring-opening polymerization (ROP) of a six membered cyclic carbonate monomer with pendant reversible addition-fragmentation chain transfer (RAFT) functionality is reported. The growth of fast propagating monomers (methyl acrylate, tetrahydropyran acrylate and N-isopropylacrylamide) from the obtained RAFT-functional poly(carbonate)s resulted in the formation of well-defined graft copolymers with a biodegradable backbone, when grafting was terminated at low monomer conversions (ca. 30%). Direct dissolution of the thermally responsive poly(carbonate)-graft-PNiPAm copolymer yielded spherical micelles as confirmed by DLS and TEM analysis.

AB - The synthesis and controlled ring-opening polymerization (ROP) of a six membered cyclic carbonate monomer with pendant reversible addition-fragmentation chain transfer (RAFT) functionality is reported. The growth of fast propagating monomers (methyl acrylate, tetrahydropyran acrylate and N-isopropylacrylamide) from the obtained RAFT-functional poly(carbonate)s resulted in the formation of well-defined graft copolymers with a biodegradable backbone, when grafting was terminated at low monomer conversions (ca. 30%). Direct dissolution of the thermally responsive poly(carbonate)-graft-PNiPAm copolymer yielded spherical micelles as confirmed by DLS and TEM analysis.

UR - https://www.scopus.com/pages/publications/84868702272

U2 - 10.1039/c2py20213a

DO - 10.1039/c2py20213a

M3 - Article

AN - SCOPUS:84868702272

SN - 1759-9954

VL - 3

SP - 2156

EP - 2164

JO - Polymer Chemistry

JF - Polymer Chemistry

IS - 8

ER -

Degradable graft copolymers by ring-opening and reverse addition-fragmentation chain transfer polymerization

Abstract

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