Degradable graft copolymers by ring-opening and reverse addition-fragmentation chain transfer polymerization

Rebecca J. Williams, Rachel K. O'Reilly, Andrew P. Dove

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14 Citations (Scopus)


The synthesis and controlled ring-opening polymerization (ROP) of a six membered cyclic carbonate monomer with pendant reversible addition-fragmentation chain transfer (RAFT) functionality is reported. The growth of fast propagating monomers (methyl acrylate, tetrahydropyran acrylate and N-isopropylacrylamide) from the obtained RAFT-functional poly(carbonate)s resulted in the formation of well-defined graft copolymers with a biodegradable backbone, when grafting was terminated at low monomer conversions (ca. 30%). Direct dissolution of the thermally responsive poly(carbonate)-graft-PNiPAm copolymer yielded spherical micelles as confirmed by DLS and TEM analysis.

Original languageEnglish
Pages (from-to)2156-2164
Number of pages9
JournalPolymer Chemistry
Issue number8
Publication statusPublished - Aug 2012
Externally publishedYes

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