Deformylation of indole and azaindole-3-carboxaldehydes using anthranilamide and solid acid heterogeneous catalyst via quinazolinone intermediate

Rammohan R. Yadav, Narsaiah Battini, Ramesh Mudududdla, Jaideep B. Bharate, Nagaraju Muparappu, Sandip B. Bharate, Ram A. Vishwakarma

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Abstract

The deformylation of indole and azaindole-3-carboxaldehydes was achieved in the presence of anthranilamide and a solid acid heterogeneous catalyst under reflux conditions in 25-90% yield. The reaction proceeds via quinazolinone intermediate, which undergoes acid catalyzed cleavage to form deformylated product.

Original languageEnglish
Pages (from-to)2222-2225
Number of pages4
JournalTetrahedron Letters
Volume53
Issue number17
DOIs
Publication statusPublished - 25 Apr 2012
Externally publishedYes

Keywords

  • Azaindole
  • Deformylation
  • Heterogeneous catalyst
  • Indole
  • Indole aldehyde
  • Quinazolinone

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