Definition and initial validation of a Lupus Low Disease Activity State (LLDAS)

Kate Franklyn, Chak Sing Lau, Sandra V Navarra, Worawit Louthrenoo, Aisha Lateef, Laniyati Hamijoyo, C Singgih Wahono, Shun Le Chen, Ou Jin, Susan Morton, Alberta Hoi, Molla Huq, Mandana Nikpour, Eric F Morand, for the Asia Pacific Lupus Collaboration

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352 Citations (Scopus)


AIMS: Treating to low disease activity is routine in rheumatoid arthritis, but no comparable goal has been defined for systemic lupus erythematosus (SLE). We sought to define and validate a Lupus Low Disease Activity State (LLDAS). METHODS: A consensus definition of LLDAS was generated using Delphi and nominal group techniques. Criterion validity was determined by measuring the ability of LLDAS attainment, in a single-centre SLE cohort, to predict non-accrual of irreversible organ damage, measured using the Systemic Lupus International Collaborating Clinics Damage Index (SDI). RESULTS: Consensus methodology led to the following definition of LLDAS: (1) SLE Disease Activity Index (SLEDAI)-2K /=1 (relative risk 0.47, 95 CI 0.28 to 0.79, p=0.005). CONCLUSIONS: A definition of LLDAS has been generated, and preliminary validation demonstrates its attainment to be associated with improved outcomes in SLE.
Original languageEnglish
Pages (from-to)1615 - 1621
Number of pages8
JournalAnnals of the Rheumatic Diseases
Publication statusPublished - 2016

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