Definition and initial validation of a Lupus Low Disease Activity State (LLDAS)

Kate Franklyn, Chak Sing Lau, Sandra V Navarra, Worawit Louthrenoo, Aisha Lateef, Laniyati Hamijoyo, C Singgih Wahono, Shun Le Chen, Ou Jin, Susan Morton, Alberta Hoi, Molla Huq, Mandana Nikpour, Eric F Morand, Asia-Pacific Lupus Collaboration

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Abstract

AIMS: Treating to low disease activity is routine in rheumatoid arthritis, but no comparable goal has been defined for systemic lupus erythematosus (SLE). We sought to define and validate a Lupus Low Disease Activity State (LLDAS). METHODS: A consensus definition of LLDAS was generated using Delphi and nominal group techniques. Criterion validity was determined by measuring the ability of LLDAS attainment, in a single-centre SLE cohort, to predict non-accrual of irreversible organ damage, measured using the Systemic Lupus International Collaborating Clinics Damage Index (SDI). RESULTS: Consensus methodology led to the following definition of LLDAS: (1) SLE Disease Activity Index (SLEDAI)-2K /=1 (relative risk 0.47, 95 CI 0.28 to 0.79, p=0.005). CONCLUSIONS: A definition of LLDAS has been generated, and preliminary validation demonstrates its attainment to be associated with improved outcomes in SLE.
Original languageEnglish
Pages (from-to)1615 - 1621
Number of pages8
JournalAnnals of the Rheumatic Diseases
Volume75
DOIs
Publication statusPublished - 2016

Cite this

Franklyn, K., Lau, C. S., Navarra, S. V., Louthrenoo, W., Lateef, A., Hamijoyo, L., ... Asia-Pacific Lupus Collaboration (2016). Definition and initial validation of a Lupus Low Disease Activity State (LLDAS). Annals of the Rheumatic Diseases, 75, 1615 - 1621. https://doi.org/10.1136/annrheumdis-2015-207726
Franklyn, Kate ; Lau, Chak Sing ; Navarra, Sandra V ; Louthrenoo, Worawit ; Lateef, Aisha ; Hamijoyo, Laniyati ; Wahono, C Singgih ; Chen, Shun Le ; Jin, Ou ; Morton, Susan ; Hoi, Alberta ; Huq, Molla ; Nikpour, Mandana ; Morand, Eric F ; Asia-Pacific Lupus Collaboration. / Definition and initial validation of a Lupus Low Disease Activity State (LLDAS). In: Annals of the Rheumatic Diseases. 2016 ; Vol. 75. pp. 1615 - 1621.
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title = "Definition and initial validation of a Lupus Low Disease Activity State (LLDAS)",
abstract = "AIMS: Treating to low disease activity is routine in rheumatoid arthritis, but no comparable goal has been defined for systemic lupus erythematosus (SLE). We sought to define and validate a Lupus Low Disease Activity State (LLDAS). METHODS: A consensus definition of LLDAS was generated using Delphi and nominal group techniques. Criterion validity was determined by measuring the ability of LLDAS attainment, in a single-centre SLE cohort, to predict non-accrual of irreversible organ damage, measured using the Systemic Lupus International Collaborating Clinics Damage Index (SDI). RESULTS: Consensus methodology led to the following definition of LLDAS: (1) SLE Disease Activity Index (SLEDAI)-2K /=1 (relative risk 0.47, 95 CI 0.28 to 0.79, p=0.005). CONCLUSIONS: A definition of LLDAS has been generated, and preliminary validation demonstrates its attainment to be associated with improved outcomes in SLE.",
author = "Kate Franklyn and Lau, {Chak Sing} and Navarra, {Sandra V} and Worawit Louthrenoo and Aisha Lateef and Laniyati Hamijoyo and Wahono, {C Singgih} and Chen, {Shun Le} and Ou Jin and Susan Morton and Alberta Hoi and Molla Huq and Mandana Nikpour and Morand, {Eric F} and {Asia-Pacific Lupus Collaboration}",
year = "2016",
doi = "10.1136/annrheumdis-2015-207726",
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Franklyn, K, Lau, CS, Navarra, SV, Louthrenoo, W, Lateef, A, Hamijoyo, L, Wahono, CS, Chen, SL, Jin, O, Morton, S, Hoi, A, Huq, M, Nikpour, M, Morand, EF & Asia-Pacific Lupus Collaboration 2016, 'Definition and initial validation of a Lupus Low Disease Activity State (LLDAS)', Annals of the Rheumatic Diseases, vol. 75, pp. 1615 - 1621. https://doi.org/10.1136/annrheumdis-2015-207726

Definition and initial validation of a Lupus Low Disease Activity State (LLDAS). / Franklyn, Kate; Lau, Chak Sing; Navarra, Sandra V; Louthrenoo, Worawit; Lateef, Aisha; Hamijoyo, Laniyati; Wahono, C Singgih; Chen, Shun Le; Jin, Ou; Morton, Susan; Hoi, Alberta; Huq, Molla; Nikpour, Mandana; Morand, Eric F; Asia-Pacific Lupus Collaboration.

In: Annals of the Rheumatic Diseases, Vol. 75, 2016, p. 1615 - 1621.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Definition and initial validation of a Lupus Low Disease Activity State (LLDAS)

AU - Franklyn, Kate

AU - Lau, Chak Sing

AU - Navarra, Sandra V

AU - Louthrenoo, Worawit

AU - Lateef, Aisha

AU - Hamijoyo, Laniyati

AU - Wahono, C Singgih

AU - Chen, Shun Le

AU - Jin, Ou

AU - Morton, Susan

AU - Hoi, Alberta

AU - Huq, Molla

AU - Nikpour, Mandana

AU - Morand, Eric F

AU - Asia-Pacific Lupus Collaboration

PY - 2016

Y1 - 2016

N2 - AIMS: Treating to low disease activity is routine in rheumatoid arthritis, but no comparable goal has been defined for systemic lupus erythematosus (SLE). We sought to define and validate a Lupus Low Disease Activity State (LLDAS). METHODS: A consensus definition of LLDAS was generated using Delphi and nominal group techniques. Criterion validity was determined by measuring the ability of LLDAS attainment, in a single-centre SLE cohort, to predict non-accrual of irreversible organ damage, measured using the Systemic Lupus International Collaborating Clinics Damage Index (SDI). RESULTS: Consensus methodology led to the following definition of LLDAS: (1) SLE Disease Activity Index (SLEDAI)-2K /=1 (relative risk 0.47, 95 CI 0.28 to 0.79, p=0.005). CONCLUSIONS: A definition of LLDAS has been generated, and preliminary validation demonstrates its attainment to be associated with improved outcomes in SLE.

AB - AIMS: Treating to low disease activity is routine in rheumatoid arthritis, but no comparable goal has been defined for systemic lupus erythematosus (SLE). We sought to define and validate a Lupus Low Disease Activity State (LLDAS). METHODS: A consensus definition of LLDAS was generated using Delphi and nominal group techniques. Criterion validity was determined by measuring the ability of LLDAS attainment, in a single-centre SLE cohort, to predict non-accrual of irreversible organ damage, measured using the Systemic Lupus International Collaborating Clinics Damage Index (SDI). RESULTS: Consensus methodology led to the following definition of LLDAS: (1) SLE Disease Activity Index (SLEDAI)-2K /=1 (relative risk 0.47, 95 CI 0.28 to 0.79, p=0.005). CONCLUSIONS: A definition of LLDAS has been generated, and preliminary validation demonstrates its attainment to be associated with improved outcomes in SLE.

U2 - 10.1136/annrheumdis-2015-207726

DO - 10.1136/annrheumdis-2015-207726

M3 - Article

VL - 75

SP - 1615

EP - 1621

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

ER -