Definition and initial validation of a Lupus Low Disease Activity State (LLDAS)

Kate Franklyn; Chak Sing Lau; Sandra V Navarra; Worawit Louthrenoo; Aisha Lateef; Laniyati Hamijoyo; C Singgih Wahono; Shun Le Chen; Ou Jin; Susan Morton; Alberta Hoi; Molla Huq; Mandana Nikpour; Eric F Morand; for the Asia Pacific Lupus Collaboration

doi:10.1136/annrheumdis-2015-207726

Definition and initial validation of a Lupus Low Disease Activity State (LLDAS)

Kate Franklyn, Chak Sing Lau, Sandra V Navarra, Worawit Louthrenoo, Aisha Lateef, Laniyati Hamijoyo, C Singgih Wahono, Shun Le Chen, Ou Jin, Susan Morton, Alberta Hoi, Molla Huq, Mandana Nikpour, Eric F Morand, for the Asia Pacific Lupus Collaboration

Medicine Monash Health

Research output: Contribution to journal › Article › Research › peer-review

463 Citations (Scopus)

Abstract

AIMS: Treating to low disease activity is routine in rheumatoid arthritis, but no comparable goal has been defined for systemic lupus erythematosus (SLE). We sought to define and validate a Lupus Low Disease Activity State (LLDAS). METHODS: A consensus definition of LLDAS was generated using Delphi and nominal group techniques. Criterion validity was determined by measuring the ability of LLDAS attainment, in a single-centre SLE cohort, to predict non-accrual of irreversible organ damage, measured using the Systemic Lupus International Collaborating Clinics Damage Index (SDI). RESULTS: Consensus methodology led to the following definition of LLDAS: (1) SLE Disease Activity Index (SLEDAI)-2K /=1 (relative risk 0.47, 95 CI 0.28 to 0.79, p=0.005). CONCLUSIONS: A definition of LLDAS has been generated, and preliminary validation demonstrates its attainment to be associated with improved outcomes in SLE.

Original language	English
Pages (from-to)	1615 - 1621
Number of pages	8
Journal	Annals of the Rheumatic Diseases
Volume	75
DOIs	https://doi.org/10.1136/annrheumdis-2015-207726
Publication status	Published - 2016

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10.1136/annrheumdis-2015-207726

Cite this

Franklyn, K., Lau, C. S., Navarra, S. V., Louthrenoo, W., Lateef, A., Hamijoyo, L., Wahono, C. S., Chen, S. L., Jin, O., Morton, S., Hoi, A., Huq, M., Nikpour, M., Morand, E. F., & for the Asia Pacific Lupus Collaboration (2016). Definition and initial validation of a Lupus Low Disease Activity State (LLDAS). Annals of the Rheumatic Diseases, 75, 1615 - 1621. https://doi.org/10.1136/annrheumdis-2015-207726

@article{79969cd813e541fb9f2b1dc8cc37b580,

title = "Definition and initial validation of a Lupus Low Disease Activity State (LLDAS)",

abstract = "AIMS: Treating to low disease activity is routine in rheumatoid arthritis, but no comparable goal has been defined for systemic lupus erythematosus (SLE). We sought to define and validate a Lupus Low Disease Activity State (LLDAS). METHODS: A consensus definition of LLDAS was generated using Delphi and nominal group techniques. Criterion validity was determined by measuring the ability of LLDAS attainment, in a single-centre SLE cohort, to predict non-accrual of irreversible organ damage, measured using the Systemic Lupus International Collaborating Clinics Damage Index (SDI). RESULTS: Consensus methodology led to the following definition of LLDAS: (1) SLE Disease Activity Index (SLEDAI)-2K /=1 (relative risk 0.47, 95 CI 0.28 to 0.79, p=0.005). CONCLUSIONS: A definition of LLDAS has been generated, and preliminary validation demonstrates its attainment to be associated with improved outcomes in SLE.",

author = "Kate Franklyn and Lau, {Chak Sing} and Navarra, {Sandra V} and Worawit Louthrenoo and Aisha Lateef and Laniyati Hamijoyo and Wahono, {C Singgih} and Chen, {Shun Le} and Ou Jin and Susan Morton and Alberta Hoi and Molla Huq and Mandana Nikpour and Morand, {Eric F} and {for the Asia Pacific Lupus Collaboration}",

year = "2016",

doi = "10.1136/annrheumdis-2015-207726",

language = "English",

volume = "75",

pages = "1615 -- 1621",

journal = "Annals of the Rheumatic Diseases",

issn = "0003-4967",

publisher = "BMJ",

}

Franklyn, K, Lau, CS, Navarra, SV, Louthrenoo, W, Lateef, A, Hamijoyo, L, Wahono, CS, Chen, SL, Jin, O, Morton, S, Hoi, A, Huq, M, Nikpour, M, Morand, EF & for the Asia Pacific Lupus Collaboration 2016, 'Definition and initial validation of a Lupus Low Disease Activity State (LLDAS)', Annals of the Rheumatic Diseases, vol. 75, pp. 1615 - 1621. https://doi.org/10.1136/annrheumdis-2015-207726

TY - JOUR

T1 - Definition and initial validation of a Lupus Low Disease Activity State (LLDAS)

AU - Franklyn, Kate

AU - Lau, Chak Sing

AU - Navarra, Sandra V

AU - Louthrenoo, Worawit

AU - Lateef, Aisha

AU - Hamijoyo, Laniyati

AU - Wahono, C Singgih

AU - Chen, Shun Le

AU - Jin, Ou

AU - Morton, Susan

AU - Hoi, Alberta

AU - Huq, Molla

AU - Nikpour, Mandana

AU - Morand, Eric F

AU - for the Asia Pacific Lupus Collaboration

PY - 2016

Y1 - 2016

N2 - AIMS: Treating to low disease activity is routine in rheumatoid arthritis, but no comparable goal has been defined for systemic lupus erythematosus (SLE). We sought to define and validate a Lupus Low Disease Activity State (LLDAS). METHODS: A consensus definition of LLDAS was generated using Delphi and nominal group techniques. Criterion validity was determined by measuring the ability of LLDAS attainment, in a single-centre SLE cohort, to predict non-accrual of irreversible organ damage, measured using the Systemic Lupus International Collaborating Clinics Damage Index (SDI). RESULTS: Consensus methodology led to the following definition of LLDAS: (1) SLE Disease Activity Index (SLEDAI)-2K /=1 (relative risk 0.47, 95 CI 0.28 to 0.79, p=0.005). CONCLUSIONS: A definition of LLDAS has been generated, and preliminary validation demonstrates its attainment to be associated with improved outcomes in SLE.

AB - AIMS: Treating to low disease activity is routine in rheumatoid arthritis, but no comparable goal has been defined for systemic lupus erythematosus (SLE). We sought to define and validate a Lupus Low Disease Activity State (LLDAS). METHODS: A consensus definition of LLDAS was generated using Delphi and nominal group techniques. Criterion validity was determined by measuring the ability of LLDAS attainment, in a single-centre SLE cohort, to predict non-accrual of irreversible organ damage, measured using the Systemic Lupus International Collaborating Clinics Damage Index (SDI). RESULTS: Consensus methodology led to the following definition of LLDAS: (1) SLE Disease Activity Index (SLEDAI)-2K /=1 (relative risk 0.47, 95 CI 0.28 to 0.79, p=0.005). CONCLUSIONS: A definition of LLDAS has been generated, and preliminary validation demonstrates its attainment to be associated with improved outcomes in SLE.

U2 - 10.1136/annrheumdis-2015-207726

DO - 10.1136/annrheumdis-2015-207726

M3 - Article

SN - 0003-4967

VL - 75

SP - 1615

EP - 1621

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

ER -