Defining the molecular blueprint that drives CD8+T cell differentiation in response to infection

Brendan E. Russ, Alice E Denton, Lauren A Hatton, Hayley A Croom, Matthew R Olson, Stephen J. Turner

Research output: Contribution to journalReview ArticleResearchpeer-review

14 Citations (Scopus)

Abstract

A cardinal feature of adaptive, cytotoxicT lymphocyte (CTL)-mediated immunity is the ability of naïve CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological memory. In this review, we examine the molecular factors that shape both the acquisition and maintenance of lineage-specific effector function in virus-specific CTL during both the effector and memory phases of immunity.

Original languageEnglish
Article numberArticle 371
JournalFrontiers in Immunology
Volume3
Issue numberDEC
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Cytotoxict cells
  • Epigenetics
  • Histone modifications
  • Memoryt cells
  • Transcription factors

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