Defining the hematopoietic stem cell niche: The chicken and the egg conundrum

Sofie Singbrant; Maria Askmyr; Louise E. Purton; Carl R. Walkley

doi:10.1002/jcb.23085

Defining the hematopoietic stem cell niche: The chicken and the egg conundrum

Sofie Singbrant, Maria Askmyr, Louise E. Purton, Carl R. Walkley

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

Understanding the in vivo regulation of hematopoietic stem cells (HSCs) will be critical to identifying key factors involved in the regulation of HSC self-renewal and differentiation. The niche (microenvironment) in which HSCs reside has recently regained attention accompanied by a dramatic increase in the understanding of the cellular constituents of the bone marrow HSC niche. The use of sophisticated genetic models allowing modulation of specific lineages has demonstrated roles for mesenchymal-derived elements such as osteoblasts and adipocytes, vasculature, nerves, and a range of hematopoietic progeny of the HSC as being participants in the regulation of the bone marrow microenvironment. Whilst providing significant insight into the cellular composition of the niche, is it possible to manipulate any given cell lineage in vivo without impacting, knowingly or unknowingly, on those that remain?

Original language	English
Pages (from-to)	1486-1490
Number of pages	5
Journal	Journal of Cellular Biochemistry
Volume	112
Issue number	6
DOIs	https://doi.org/10.1002/jcb.23085
Publication status	Published - Jun 2011
Externally published	Yes

Keywords

hematopoietic stem cell
microenvironment
niche

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10.1002/jcb.23085

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AB - Understanding the in vivo regulation of hematopoietic stem cells (HSCs) will be critical to identifying key factors involved in the regulation of HSC self-renewal and differentiation. The niche (microenvironment) in which HSCs reside has recently regained attention accompanied by a dramatic increase in the understanding of the cellular constituents of the bone marrow HSC niche. The use of sophisticated genetic models allowing modulation of specific lineages has demonstrated roles for mesenchymal-derived elements such as osteoblasts and adipocytes, vasculature, nerves, and a range of hematopoietic progeny of the HSC as being participants in the regulation of the bone marrow microenvironment. Whilst providing significant insight into the cellular composition of the niche, is it possible to manipulate any given cell lineage in vivo without impacting, knowingly or unknowingly, on those that remain?

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Defining the hematopoietic stem cell niche: The chicken and the egg conundrum

Abstract

Keywords

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