@article{533b1d7ca3c04c0f93e80371e5747f09,
title = "Defining Target Vancomycin Trough Concentrations for Treating Staphylococcus aureus Infection in Infants Aged 0 to 90 Days",
author = "Amanda Gwee and Noel Cranswick and Brendan McMullan and Srinivas Bolisetty and Hunt, \{Rodney W.\} and Nigel Curtis and Duffull, \{Stephen B.\}",
note = "Funding Information: Conflict of Interest Disclosures: None reported. Funding/Support: Staff and materials for data collection for this work were funded by the Murdoch Children{\textquoteright}s Research Institute. Dr Gwee received stipend support from the Royal Australasian College of Physicians Basser Research Entry Scholarship as well as a National Health and Medical Research Council postgraduate scholarship GNT1150216. Role of the Funder/Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. 1. Moise-Broder PA, Forrest A, Birmingham MC, Schentag JJ. Pharmacodynamics of vancomycin and other antimicrobials in patients with Staphylococcus aureus lower respiratory tract infections. Clin Pharmacokinet. 2004;43(13):925-942. doi:10.2165/00003088-200443130-00005 2. Holmes NE, Turnidge JD, Munckhof WJ, et al. Vancomycin AUC/MIC ratio and 30-day mortality in patients with Staphylococcus aureus bacteremia. Antimicrob Agents Chemother. 2013;57(4):1654-1663. doi:10.1128/AAC.01485-12 3. Anderson BJ, Holford NH. Understanding dosing: children are small adults, neonates are immature children. Arch Dis Child. 2013;98(9):737-744. doi:10. 1136/archdischild-2013-303720 4. Gwee A, Cranswick N, McMullan B, et al. Continuous versus intermittent vancomycin infusions in infants: a randomized controlled trial. Pediatrics. 2019; 143(2):e20182179. doi:10.1542/peds.2018-2179 5. Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary. Clin Infect Dis. 2011;52(3):285-292. doi:10.1093/cid/cir034 6. Frymoyer A, Hersh AL, El-Komy MH, et al. Association between vancomycin trough concentration and area under the concentration-time curve in neonates. Antimicrob Agents Chemother. 2014;58(11):6454-6461. doi:10.1128/AAC.03620-14 Funding Information: Funding/Support: Preparation of the manuscript was supported in part by the National Institute of Mental Health of the National Institutes of Health (grants R01MH101138, R01MH115905, and R21MH112055), as well as by the American Psychological Foundation Wayne F. Placek Grant. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2019",
month = aug,
doi = "10.1001/jamapediatrics.2019.1488",
language = "English",
volume = "173",
pages = "791--793",
journal = "JAMA Pediatrics",
issn = "2168-6203",
publisher = "American Medical Association (AMA)",
number = "8",
}