Defining key questions for clinical practice guidelines: A novel approach for developing clinically relevant questions

Samantha Chakraborty, Bianca Brijnath, Jacinta Dermentzis, Danielle Mazza

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)


Background: There is no standardised protocol for developing clinically relevant guideline questions. We aimed to create such a protocol and to apply it to developing a new guideline. Methods: We reviewed international guideline manuals and, through consensus, combined steps for developing clinical questions to produce a best-practice protocol that incorporated qualitative research. The protocol was applied to develop clinical questions for a guideline for general practitioners. Results: A best-practice protocol incorporating qualitative research was created. Using the protocol, we developed 10 clinical questions that spanned diagnosis, management and follow-up. Conclusions: Guideline developers can apply this protocol to develop clinically relevant guideline questions.

Original languageEnglish
Article number113
Number of pages9
JournalHealth Research Policy and Systems
Issue number1
Publication statusPublished - 29 Sep 2020


  • Clinical judgement
  • Clinical practice guideline
  • General practitioner
  • GP
  • Guideline manual
  • Guideline methodology
  • Guideline scope
  • Implementation
  • Key clinical questions

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