Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury

Bridgette D Semple, Nicole Bye, Jenna Mical Ziebell, Maria Cristina Morganti-Kossmann

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87 Citations (Scopus)

Abstract

The contribution of infiltrated neutrophils to secondary damage following traumatic brain injury remains controversial. Chemokines that regulate neutrophil migration by signaling through the CXCR2 receptor are markedly elevated by brain injury and are associated with the propagation of secondary damage. This study thus investigated the function of CXCR2 in posttraumatic inflammation and secondary degeneration by examining Cxcr2-deficient (Cxcr2-/-) mice over 14 days following closed head injury (CHI).
Original languageEnglish
Pages (from-to)394 - 403
Number of pages10
JournalNeurobiology of Disease
Volume40
Issue number2
DOIs
Publication statusPublished - 2010

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