Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury

Bridgette D Semple, Nicole Bye, Jenna Mical Ziebell, Maria Cristina Morganti-Kossmann

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Abstract

The contribution of infiltrated neutrophils to secondary damage following traumatic brain injury remains controversial. Chemokines that regulate neutrophil migration by signaling through the CXCR2 receptor are markedly elevated by brain injury and are associated with the propagation of secondary damage. This study thus investigated the function of CXCR2 in posttraumatic inflammation and secondary degeneration by examining Cxcr2-deficient (Cxcr2-/-) mice over 14 days following closed head injury (CHI).
Original languageEnglish
Pages (from-to)394 - 403
Number of pages10
JournalNeurobiology of Disease
Volume40
Issue number2
DOIs
Publication statusPublished - 2010

Cite this

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title = "Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury",
abstract = "The contribution of infiltrated neutrophils to secondary damage following traumatic brain injury remains controversial. Chemokines that regulate neutrophil migration by signaling through the CXCR2 receptor are markedly elevated by brain injury and are associated with the propagation of secondary damage. This study thus investigated the function of CXCR2 in posttraumatic inflammation and secondary degeneration by examining Cxcr2-deficient (Cxcr2-/-) mice over 14 days following closed head injury (CHI).",
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Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury. / Semple, Bridgette D; Bye, Nicole; Ziebell, Jenna Mical; Morganti-Kossmann, Maria Cristina.

In: Neurobiology of Disease, Vol. 40, No. 2, 2010, p. 394 - 403.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury

AU - Semple, Bridgette D

AU - Bye, Nicole

AU - Ziebell, Jenna Mical

AU - Morganti-Kossmann, Maria Cristina

PY - 2010

Y1 - 2010

N2 - The contribution of infiltrated neutrophils to secondary damage following traumatic brain injury remains controversial. Chemokines that regulate neutrophil migration by signaling through the CXCR2 receptor are markedly elevated by brain injury and are associated with the propagation of secondary damage. This study thus investigated the function of CXCR2 in posttraumatic inflammation and secondary degeneration by examining Cxcr2-deficient (Cxcr2-/-) mice over 14 days following closed head injury (CHI).

AB - The contribution of infiltrated neutrophils to secondary damage following traumatic brain injury remains controversial. Chemokines that regulate neutrophil migration by signaling through the CXCR2 receptor are markedly elevated by brain injury and are associated with the propagation of secondary damage. This study thus investigated the function of CXCR2 in posttraumatic inflammation and secondary degeneration by examining Cxcr2-deficient (Cxcr2-/-) mice over 14 days following closed head injury (CHI).

UR - http://www.ncbi.nlm.nih.gov/pubmed/20621186

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EP - 403

JO - Neurobiology of Disease

JF - Neurobiology of Disease

SN - 0969-9961

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ER -