Deficiencies in the CD19 complex

Marjolein W.J. Wentink, Menno C. van Zelm, Jacques J.M. van Dongen, Klaus Warnatz, Mirjam van der Burg

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)


Signaling via the CD19-complex, consisting of CD19, CD81, CD21 and CD225, is critically important for B-cell development, differentiation and maturation. In this complex, each protein has its own distinct function. Over the past decade, 15 patients with antibody deficiency due to deficiencies in the CD19-complex have been described. These patients have deficiencies in different complex-members, all caused by either homozygous or compound heterozygous mutations. Although all patients had antibody deficiencies, the clinical phenotype was different per deficient protein. We aimed to provide an overview of what is known about the function of the different complex-members, knowledge from mouse-studies and to summarize the clinical phenotypes of the patients. Combining this knowledge together can explain why deficiencies in different members of the same complex, result in disease phenotypes that are alike, but not the same.

Original languageEnglish
Pages (from-to)82-87
Number of pages6
JournalClinical Immunology
Publication statusPublished - 1 Oct 2018


  • B-cell receptor co-complex
  • CD19
  • CD21
  • CD81
  • Primary antibody deficiencies

Cite this

Wentink, M. W. J., van Zelm, M. C., van Dongen, J. J. M., Warnatz, K., & van der Burg, M. (2018). Deficiencies in the CD19 complex. Clinical Immunology, 195, 82-87.