Decreased renal responses to atrial natriuretic peptide in renal wrap hypertension

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Abstract

The effects of atrial natriuretic polypeptide (ANP) on renal function were examined in renal wrap hypertensive rabbits and sham operated rabbits. ANP (2 μg/min) induced hypotension, but did not produce significant diuresis, natriuresis or change in the glomerular filtration rate (GFR) in renal wrap hypertensive rabbits (n = 8). In sham operated normotensive rabbits (n = 4), ANP induced significant diuresis (230%) and increased GFR by about 40%. Thus, ANP was markedly less effective in the impaired kidneys of renal wrapped rabbits than in normal kidneys.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalClinical and Experimental Pharmacology and Physiology
Volume15
Issue number4
Publication statusPublished - 1988
Externally publishedYes

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