Decreased perfusion in young alcohol-dependent women as compared with age-matched controls

Camellia P. Clark, Gregory G. Brown, Lisa T. Eyler, Sean P.A. Drummond, Deborah R. Braun, Susan F. Tapert

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26 Citations (Scopus)

Abstract

Aim: To use the superior spatial resolution of magnetic resonance imaging (MRI) to examine differences in cerebral perfusion between young alcohol dependent and normal women. Methods: Eight alcohol dependent women and 8 controls (all ages 18-25) received single-slice resting perfusion-weighted MRI (directly proportional to brain blood flow), with slices located above the corpus callosum. Results: Alcohol-dependent women had decreased perfusion in prefrontal and left parietal regions. Conclusions: Reduced perfusion has not previously been reported in young, physically healthy alcohol dependent females, yet is consistent with previously reported decreased cerebral activity in alcohol dependence.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalAmerican Journal of Drug and Alcohol Abuse
Volume33
Issue number1
DOIs
Publication statusPublished - 1 Jan 2007
Externally publishedYes

Keywords

  • Alcohol abuse
  • Alcoholism
  • Perfusion magnetic resonance imaging

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