Decreased blood-brain barrier expression of P-glycoprotein in alzheimer's disease: Impact on pathogenesis and brain access of therapeutic agents

The blooda??brain barrier (BBB), formed by the endothelial cells lining the cerebral microvasculature, was once thought to act as a simple physical barrier protecting the brain parenchyma from blood-borne agents. However, with the revitalization of cerebral vascular research, it is becoming more recognized that the BBB is a dynamic interface that plays a critical role in communication between the sensitive CNS and the periphery.