Decreased blood-brain barrier expression of P-glycoprotein in alzheimer's disease: Impact on pathogenesis and brain access of therapeutic agents

Joseph Nicolazzo, William Banks

Research output: Contribution to journalEditorialResearchpeer-review

6 Citations (Scopus)

Abstract

The blooda??brain barrier (BBB), formed by the endothelial cells lining the cerebral microvasculature, was once thought to act as a simple physical barrier protecting the brain parenchyma from blood-borne agents. However, with the revitalization of cerebral vascular research, it is becoming more recognized that the BBB is a dynamic interface that plays a critical role in communication between the sensitive CNS and the periphery.
Original languageEnglish
Pages (from-to)841 - 844
Number of pages4
JournalTherapeutic Delivery
Volume2
Issue number7
DOIs
Publication statusPublished - 2011

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