Decreased blood-brain barrier expression of P-glycoprotein in alzheimer's disease: Impact on pathogenesis and brain access of therapeutic agents

Joseph Nicolazzo, William Banks

Research output: Contribution to journalEditorialResearchpeer-review

4 Citations (Scopus)

Abstract

The blooda??brain barrier (BBB), formed by the endothelial cells lining the cerebral microvasculature, was once thought to act as a simple physical barrier protecting the brain parenchyma from blood-borne agents. However, with the revitalization of cerebral vascular research, it is becoming more recognized that the BBB is a dynamic interface that plays a critical role in communication between the sensitive CNS and the periphery.
Original languageEnglish
Pages (from-to)841 - 844
Number of pages4
JournalTherapeutic Delivery
Volume2
Issue number7
DOIs
Publication statusPublished - 2011

Cite this

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title = "Decreased blood-brain barrier expression of P-glycoprotein in alzheimer's disease: Impact on pathogenesis and brain access of therapeutic agents",
abstract = "The blooda??brain barrier (BBB), formed by the endothelial cells lining the cerebral microvasculature, was once thought to act as a simple physical barrier protecting the brain parenchyma from blood-borne agents. However, with the revitalization of cerebral vascular research, it is becoming more recognized that the BBB is a dynamic interface that plays a critical role in communication between the sensitive CNS and the periphery.",
author = "Joseph Nicolazzo and William Banks",
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Decreased blood-brain barrier expression of P-glycoprotein in alzheimer's disease: Impact on pathogenesis and brain access of therapeutic agents. / Nicolazzo, Joseph; Banks, William.

In: Therapeutic Delivery, Vol. 2, No. 7, 2011, p. 841 - 844.

Research output: Contribution to journalEditorialResearchpeer-review

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AU - Nicolazzo, Joseph

AU - Banks, William

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AB - The blooda??brain barrier (BBB), formed by the endothelial cells lining the cerebral microvasculature, was once thought to act as a simple physical barrier protecting the brain parenchyma from blood-borne agents. However, with the revitalization of cerebral vascular research, it is becoming more recognized that the BBB is a dynamic interface that plays a critical role in communication between the sensitive CNS and the periphery.

U2 - 10.4155/TDE.11.65

DO - 10.4155/TDE.11.65

M3 - Editorial

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EP - 844

JO - Therapeutic Delivery

JF - Therapeutic Delivery

SN - 2041-5990

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