Decorated self-assembling β3-tripeptide foldamers form cell adhesive scaffolds

Kerstin Luder; Ketav Kulkarni; Huey Wen Lee; Robert E. Widdop; Mark P. Del Borgo; Marie-Isabel Aguilar

doi:10.1039/c6cc00247a

Decorated self-assembling β³-tripeptide foldamers form cell adhesive scaffolds

Kerstin Luder, Ketav Kulkarni, Huey Wen Lee, Robert E. Widdop, Mark P. Del Borgo, Marie-Isabel Aguilar

Research output: Contribution to journal › Article › Research › peer-review

32 Citations (Scopus)

Abstract

A popular strategy to control cellular growth and differentiation is the employment of self-assembling peptides as biomaterials. In this study we decorated ultrashort helical N-acetylated β-tripeptides with cell adhesion signals IKVAV and RGD, which spontaneously self-assemble to give nanofibres with multiple signals, and form a bioscaffold that supports the growth of cells.

Original language	English
Pages (from-to)	4549-4552
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	24
DOIs	https://doi.org/10.1039/c6cc00247a
Publication status	Published - 29 Feb 2016

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10.1039/c6cc00247a

Cite this

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title = "Decorated self-assembling β3-tripeptide foldamers form cell adhesive scaffolds",

abstract = "A popular strategy to control cellular growth and differentiation is the employment of self-assembling peptides as biomaterials. In this study we decorated ultrashort helical N-acetylated β-tripeptides with cell adhesion signals IKVAV and RGD, which spontaneously self-assemble to give nanofibres with multiple signals, and form a bioscaffold that supports the growth of cells.",

author = "Kerstin Luder and Ketav Kulkarni and Lee, \{Huey Wen\} and Widdop, \{Robert E.\} and \{Del Borgo\}, \{Mark P.\} and Marie-Isabel Aguilar",

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AU - Luder, Kerstin

AU - Kulkarni, Ketav

AU - Lee, Huey Wen

AU - Widdop, Robert E.

AU - Del Borgo, Mark P.

AU - Aguilar, Marie-Isabel

PY - 2016/2/29

Y1 - 2016/2/29

N2 - A popular strategy to control cellular growth and differentiation is the employment of self-assembling peptides as biomaterials. In this study we decorated ultrashort helical N-acetylated β-tripeptides with cell adhesion signals IKVAV and RGD, which spontaneously self-assemble to give nanofibres with multiple signals, and form a bioscaffold that supports the growth of cells.

AB - A popular strategy to control cellular growth and differentiation is the employment of self-assembling peptides as biomaterials. In this study we decorated ultrashort helical N-acetylated β-tripeptides with cell adhesion signals IKVAV and RGD, which spontaneously self-assemble to give nanofibres with multiple signals, and form a bioscaffold that supports the growth of cells.

UR - http://www.ncbi.nlm.nih.gov/pubmed/26940541

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DO - 10.1039/c6cc00247a

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VL - 52

SP - 4549

EP - 4552

JO - Chemical Communications

JF - Chemical Communications

IS - 24

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Decorated self-assembling β3-tripeptide foldamers form cell adhesive scaffolds

Abstract

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Decorated self-assembling β³-tripeptide foldamers form cell adhesive scaffolds