Decline in beta hCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success: A retrospective cohort study

Monika Michalina Skubisz, Jourena Li, Euan Wallace, Stephen Tong

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Abstract

In current protocols for the medical management of ectopic pregnancies, the first indication of treatment response is obtained no sooner than day 7. We examined whether human chorionic gonadotrophin (betahCG) trends between days 0 and 4 after methotrexate provide an earlier indication of the likely outcome. Of 33 patients where serum betahCG dropped between days 0 and 4 after methotrexate, the ectopic pregnancy was resolved in 88 of cases without further treatment. Of 12 women where serum betahCG rose between days 0 and 4, only 42 had treatment success. A fall in betahCG between days 0 and 4 after treatment with methotrexate for ectopic pregnancy predicts a high likelihood of treatment success.
Original languageEnglish
Pages (from-to)1665 - 1668
Number of pages4
JournalBJOG: an International Journal of Obstetrics and Gynaecology
Volume118
Issue number13
DOIs
Publication statusPublished - 2011

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