Deciphering the transcriptional network of the dendritic cell lineage

Jennifer C Miller, Brian D Brown, Tal Shay, Emmanuel L Gautier, Vladimir Jojic, Ariella Cohain, Gaurav Pandey, Marylene Leboeuf, Kutlu G Elpek, Julie Helft, Daigo Hashimoto, Andrew Chow, Jeremy Price, Melanie Greter, Milena Bogunovic, Angelique Bellemare-Pelletier, Paul S Frenette, Gwendalyn J Randolph, Shannon J Turley, Miriam MeradClaudia V Jakubzick, J Adam Best, Jamie Knell, Ananda W Goldrath, Daphne Koller, Nadia R Cohen, Patrick J Brennan, Michael P Brenner, Aviv Regev, Anne Fletcher, Deepali Malhotra, Radu Jianu, David H Laidlaw, Jim J Collins, Kavitha Narayan, Katelyn Sylvia, Joonsoo Kang, Roi Gazit, Derrick J Rossi, Francis S Kim, Tata N Rao, Amy Wagers, Susan A Shinton, Richard R Hardy, Paul Monach, Natalie A Bezman, Joseph C Sun, Charlie C Kim, Lewis L Lanier, Tracy S P Heng, Taras Kreslavsky, Michio W Painter, Jeffrey A Ericson, Scott P Davis, Diane Mathis, Christophe Benoist

Research output: Contribution to journalArticleResearchpeer-review

484 Citations (Scopus)

Abstract

Although much progress has been made in the understanding of the ontogeny and function of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and functional specialization of DCs in vivo remains poorly understood. We made a comprehensive comparative analysis of CD8(+), CD103(+), CD11b(+) and plasmacytoid DC subsets, as well as macrophage DC precursors and common DC precursors, across the entire immune system. Here we characterized candidate transcriptional activators involved in the commitment of myeloid progenitor cells to the DC lineage and predicted regulators of DC functional diversity in tissues. We identified a molecular signature that distinguished tissue DCs from macrophages. We also identified a transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens.
Original languageEnglish
Pages (from-to)888 - 889
Number of pages2
JournalNature Immunology
Volume13
Issue number9
DOIs
Publication statusPublished - 2012
Externally publishedYes

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