Deciphering the mechanisms of gene silencing induced by triplet-repeat expansions

Sridevi Sureshkumar; Sureshkumar Balasubramanian

doi:10.1038/s41477-024-01673-4

Deciphering the mechanisms of gene silencing induced by triplet-repeat expansions

Sridevi Sureshkumar, Sureshkumar Balasubramanian

School of Biological Sciences

Research output: Contribution to journal › Comment / Debate › Other › peer-review

Abstract

A triplet repeat expansion in Arabidopsis induces gene silencing that results in a severe growth defect. We show that an interplay between a SUMO protease and histone readers of active and inactive marks is required for this gene silencing, which highlights the importance of post-translational modifiers in chromatin remodelling.

Original language	English
Pages (from-to)	708-709
Number of pages	2
Journal	Nature Plants
Volume	10
Issue number	5
DOIs	https://doi.org/10.1038/s41477-024-01673-4
Publication status	Published - May 2024

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abstract = "A triplet repeat expansion in Arabidopsis induces gene silencing that results in a severe growth defect. We show that an interplay between a SUMO protease and histone readers of active and inactive marks is required for this gene silencing, which highlights the importance of post-translational modifiers in chromatin remodelling.",

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Deciphering the mechanisms of gene silencing induced by triplet-repeat expansions

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