DEC-205 is a cell surface receptor for CpG oligonucleotides

Irina Caminschi; Simone Meuter; William R Heath

doi:10.4161/onci.23128

DEC-205 is a cell surface receptor for CpG oligonucleotides

Irina Caminschi, Simone Meuter, William R Heath

Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)

Abstract

We have recently demonstrated that synthetic CpG oligonucleotides (ODNs), which function as potent immunostimulators, bind to the multi-lectin receptor DEC-205, resulting in their internalization. DEC-205-deficient mice exhibit impaired dendritic-cell and B-cell maturation, impaired cytokine responses and suboptimal cytotoxic T-cell responses. As murine and human DEC-205 are highly conserved, CpG ODNs destined to clinical applications should be designed to maximize DEC-205 binding.

Original language	English
Article number	e23128
Journal	OncoImmunology
Volume	2
Issue number	3
DOIs	https://doi.org/10.4161/onci.23128
Publication status	Published - Mar 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adjuvants
CpG
Dendritic cells
TLR9
Vaccines

Access to Document

10.4161/onci.23128

Cite this

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title = "DEC-205 is a cell surface receptor for CpG oligonucleotides",

abstract = "We have recently demonstrated that synthetic CpG oligonucleotides (ODNs), which function as potent immunostimulators, bind to the multi-lectin receptor DEC-205, resulting in their internalization. DEC-205-deficient mice exhibit impaired dendritic-cell and B-cell maturation, impaired cytokine responses and suboptimal cytotoxic T-cell responses. As murine and human DEC-205 are highly conserved, CpG ODNs destined to clinical applications should be designed to maximize DEC-205 binding.",

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author = "Irina Caminschi and Simone Meuter and Heath, \{William R\}",

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AU - Caminschi, Irina

AU - Meuter, Simone

AU - Heath, William R

PY - 2013/3

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N2 - We have recently demonstrated that synthetic CpG oligonucleotides (ODNs), which function as potent immunostimulators, bind to the multi-lectin receptor DEC-205, resulting in their internalization. DEC-205-deficient mice exhibit impaired dendritic-cell and B-cell maturation, impaired cytokine responses and suboptimal cytotoxic T-cell responses. As murine and human DEC-205 are highly conserved, CpG ODNs destined to clinical applications should be designed to maximize DEC-205 binding.

AB - We have recently demonstrated that synthetic CpG oligonucleotides (ODNs), which function as potent immunostimulators, bind to the multi-lectin receptor DEC-205, resulting in their internalization. DEC-205-deficient mice exhibit impaired dendritic-cell and B-cell maturation, impaired cytokine responses and suboptimal cytotoxic T-cell responses. As murine and human DEC-205 are highly conserved, CpG ODNs destined to clinical applications should be designed to maximize DEC-205 binding.

KW - Adjuvants

KW - CpG

KW - Dendritic cells

KW - TLR9

KW - Vaccines

UR - https://www.scopus.com/pages/publications/84886945194

U2 - 10.4161/onci.23128

DO - 10.4161/onci.23128

M3 - Article

AN - SCOPUS:84886945194

SN - 2162-4011

VL - 2

JO - OncoImmunology

JF - OncoImmunology

IS - 3

M1 - e23128

ER -

DEC-205 is a cell surface receptor for CpG oligonucleotides

Abstract

UN SDGs

Keywords

Access to Document

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