DEC-205 is a cell surface receptor for CpG oligonucleotides

Irina Caminschi, Simone Meuter, William R Heath

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

We have recently demonstrated that synthetic CpG oligonucleotides (ODNs), which function as potent immunostimulators, bind to the multi-lectin receptor DEC-205, resulting in their internalization. DEC-205-deficient mice exhibit impaired dendritic-cell and B-cell maturation, impaired cytokine responses and suboptimal cytotoxic T-cell responses. As murine and human DEC-205 are highly conserved, CpG ODNs destined to clinical applications should be designed to maximize DEC-205 binding.

Original languageEnglish
Article numbere23128
JournalOncoImmunology
Volume2
Issue number3
DOIs
Publication statusPublished - Mar 2013
Externally publishedYes

Keywords

  • Adjuvants
  • CpG
  • Dendritic cells
  • TLR9
  • Vaccines

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