Abstract
Human immunodeficiency virus 1 (HIV-1) aspartyl protease performs a critically important step in the viral life cycle. Immature viral Gag and Gag-Pol polyproteins are processed by cleavage to form structural and enzyme components, before assembly into nascent, infectious virions. Darunavir is a synthetic nonpeptidyl small molecule analog of amprenavir that inhibits the dimerization and catalytic activity of the protease enzyme (Hayashi et al., 2014; Koh et al., 2007), thereby preventing viral maturation. The chemical structure is similar to that of amprenavir; however, the terminal tetrahydrofuran (THF) group is fused to a second THF group, to form a bis-THF moiety.
| Original language | English |
|---|---|
| Title of host publication | Kucers the Use of Antibiotics |
| Subtitle of host publication | A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs |
| Editors | M. Lindsay Grayson |
| Place of Publication | Boca Raton FL USA |
| Publisher | CRC Press |
| Chapter | 245 |
| Pages | 4125-4141 |
| Number of pages | 17 |
| Edition | 7th |
| ISBN (Electronic) | 9781498747967 |
| ISBN (Print) | 9781498747950 |
| Publication status | Published - 2 Oct 2017 |
