Dangerous liaisons between interleukin-6 cytokine and toll-like receptor families: a potent combination in inflammation and cancer

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Abstract

The potent pro-inflammatory actions of members of the interleukin (IL)-6 cytokine and toll-like receptor (TLR) families have been implicated in numerous inflammatory disorders, as well as inflammation-associated cancers. It is fast becoming apparent that a hallmark of many such inflammatory-related diseases is the overlapping deregulated expression of members of each family, and the consequent augmented activation of shared signaling pathways. Here, we review the molecular basis by which the IL-6 cytokine and TLR family signaling networks are regulated, and integrate recent advances exploring the intimate cross-regulation of these two families which may provide the foundation for the future development of therapeutics to target chronic inflammation-associated diseases, including cancer.
Original languageEnglish
Pages (from-to)249 - 256
Number of pages8
JournalCytokine and Growth Factor Reviews
Volume24
Issue number3
DOIs
Publication statusPublished - 2013

Cite this

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title = "Dangerous liaisons between interleukin-6 cytokine and toll-like receptor families: a potent combination in inflammation and cancer",
abstract = "The potent pro-inflammatory actions of members of the interleukin (IL)-6 cytokine and toll-like receptor (TLR) families have been implicated in numerous inflammatory disorders, as well as inflammation-associated cancers. It is fast becoming apparent that a hallmark of many such inflammatory-related diseases is the overlapping deregulated expression of members of each family, and the consequent augmented activation of shared signaling pathways. Here, we review the molecular basis by which the IL-6 cytokine and TLR family signaling networks are regulated, and integrate recent advances exploring the intimate cross-regulation of these two families which may provide the foundation for the future development of therapeutics to target chronic inflammation-associated diseases, including cancer.",
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AU - Mansell, Ashley Scott

AU - Jenkins, Brendan John

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N2 - The potent pro-inflammatory actions of members of the interleukin (IL)-6 cytokine and toll-like receptor (TLR) families have been implicated in numerous inflammatory disorders, as well as inflammation-associated cancers. It is fast becoming apparent that a hallmark of many such inflammatory-related diseases is the overlapping deregulated expression of members of each family, and the consequent augmented activation of shared signaling pathways. Here, we review the molecular basis by which the IL-6 cytokine and TLR family signaling networks are regulated, and integrate recent advances exploring the intimate cross-regulation of these two families which may provide the foundation for the future development of therapeutics to target chronic inflammation-associated diseases, including cancer.

AB - The potent pro-inflammatory actions of members of the interleukin (IL)-6 cytokine and toll-like receptor (TLR) families have been implicated in numerous inflammatory disorders, as well as inflammation-associated cancers. It is fast becoming apparent that a hallmark of many such inflammatory-related diseases is the overlapping deregulated expression of members of each family, and the consequent augmented activation of shared signaling pathways. Here, we review the molecular basis by which the IL-6 cytokine and TLR family signaling networks are regulated, and integrate recent advances exploring the intimate cross-regulation of these two families which may provide the foundation for the future development of therapeutics to target chronic inflammation-associated diseases, including cancer.

UR - http://www.sciencedirect.com/science/article/pii/S1359610113000270

U2 - 10.1016/j.cytogfr.2013.03.007

DO - 10.1016/j.cytogfr.2013.03.007

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EP - 256

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

SN - 1359-6101

IS - 3

ER -