Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 249 - 256 |
| Number of pages | 8 |
| Journal | Cytokine and Growth Factor Reviews |
| Volume | 24 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2013 |
Cite this
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Dangerous liaisons between interleukin-6 cytokine and toll-like receptor families: a potent combination in inflammation and cancer. / Mansell, Ashley Scott; Jenkins, Brendan John.
In: Cytokine and Growth Factor Reviews, Vol. 24, No. 3, 2013, p. 249 - 256.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Dangerous liaisons between interleukin-6 cytokine and toll-like receptor families: a potent combination in inflammation and cancer
AU - Mansell, Ashley Scott
AU - Jenkins, Brendan John
PY - 2013
Y1 - 2013
N2 - The potent pro-inflammatory actions of members of the interleukin (IL)-6 cytokine and toll-like receptor (TLR) families have been implicated in numerous inflammatory disorders, as well as inflammation-associated cancers. It is fast becoming apparent that a hallmark of many such inflammatory-related diseases is the overlapping deregulated expression of members of each family, and the consequent augmented activation of shared signaling pathways. Here, we review the molecular basis by which the IL-6 cytokine and TLR family signaling networks are regulated, and integrate recent advances exploring the intimate cross-regulation of these two families which may provide the foundation for the future development of therapeutics to target chronic inflammation-associated diseases, including cancer.
AB - The potent pro-inflammatory actions of members of the interleukin (IL)-6 cytokine and toll-like receptor (TLR) families have been implicated in numerous inflammatory disorders, as well as inflammation-associated cancers. It is fast becoming apparent that a hallmark of many such inflammatory-related diseases is the overlapping deregulated expression of members of each family, and the consequent augmented activation of shared signaling pathways. Here, we review the molecular basis by which the IL-6 cytokine and TLR family signaling networks are regulated, and integrate recent advances exploring the intimate cross-regulation of these two families which may provide the foundation for the future development of therapeutics to target chronic inflammation-associated diseases, including cancer.
UR - http://www.sciencedirect.com/science/article/pii/S1359610113000270
U2 - 10.1016/j.cytogfr.2013.03.007
DO - 10.1016/j.cytogfr.2013.03.007
M3 - Article
VL - 24
SP - 249
EP - 256
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
SN - 1359-6101
IS - 3
ER -