Danger signals in stroke

Mathias Gelderblom, Christopher G Sobey, Christoph Kleinschnitz, Tim Magnus

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

Danger molecules are the first signals released from dying tissue after stroke. These danger signals bind to receptors on immune cells that will result in their activation and the release of inflammatory and neurotoxic mediators, resulting in amplification of the immune response and subsequent enlargement of the damaged brain volume. The release of danger signals is a central event that leads to a multitude of signals and cascades in the affected and neighbouring tissue, therefore providing a potential target for therapy.
Original languageEnglish
Pages (from-to)77 - 82
Number of pages6
JournalAgeing Research Reviews
Volume24
Issue numberPt. A
DOIs
Publication statusPublished - 2015

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