TY - JOUR
T1 - Danger signals in stroke
AU - Gelderblom, Mathias
AU - Sobey, Christopher G
AU - Kleinschnitz, Christoph
AU - Magnus, Tim
PY - 2015
Y1 - 2015
N2 - Danger molecules are the first signals released from dying tissue after stroke. These danger signals bind to receptors on immune cells that will result in their activation and the release of inflammatory and neurotoxic mediators, resulting in amplification of the immune response and subsequent enlargement of the damaged brain volume. The release of danger signals is a central event that leads to a multitude of signals and cascades in the affected and neighbouring tissue, therefore providing a potential target for therapy.
AB - Danger molecules are the first signals released from dying tissue after stroke. These danger signals bind to receptors on immune cells that will result in their activation and the release of inflammatory and neurotoxic mediators, resulting in amplification of the immune response and subsequent enlargement of the damaged brain volume. The release of danger signals is a central event that leads to a multitude of signals and cascades in the affected and neighbouring tissue, therefore providing a potential target for therapy.
UR - http://www.ncbi.nlm.nih.gov/pubmed/26210897
U2 - 10.1016/j.arr.2015.07.004
DO - 10.1016/j.arr.2015.07.004
M3 - Article
SN - 1568-1637
VL - 24
SP - 77
EP - 82
JO - Ageing Research Reviews
JF - Ageing Research Reviews
IS - Pt. A
ER -