Daily allergic multimorbidity in rhinitis using mobile technology

A novel concept of the MASK study

J. Bousquet, P. Devillier, J. M. Anto, M. Bewick, T. Haahtela, S. Arnavielhe, A. Bedbrook, R. Murray, M. van Eerd, J. A. Fonseca, M. Morais Almeida, A. Todo Bom, E. Menditto, G. Passalacqua, C. Stellato, M. Triggiani, M. T. Ventura, G. Vezzani, I. Annesi-Maesano, R. Bourret & 61 others I. Bosse, D. Caimmi, C. Cartier, P. Demoly, J. Just, F. Portejoie, V. Siroux, F. Viart, K. C. Bergmann, T. Keil, L. Klimek, R. Mösges, O. Pfaar, S. Shamai, T. Zuberbier, J. Mullol, A. Valero, O. Spranger, P. V. Tomazic, M. L. Kowalski, P. Kuna, M. Kupczyk, F. Raciborski, B. Samolinski, S. K. Toppila-Salmi, E. Valovirta, A. A. Cruz, F. Sarquis-Serpa, J. da Silva, R. Stelmach, D. Larenas-Linnemann, M. Rodriguez Gonzalez, M. T. Burguete Cabañas, V. Kvedariene, A. Valiulis, N. H. Chavannes, W. J. Fokkens, D. Ryan, A. Sheikh, C. Bachert, P. W. Hellings, O. VandenPlas, N. Ballardini, I. Kull, E. Melén, M. Westman, M. Wickman, C. Bindslev-Jensen, E. Eller, S. Bosnic-Anticevich, R. E. O'Hehir, I. Agache, T. Bieber, T. Casale, B. Gemicioğlu, J. C. Ivancevich, G. De Vries, M. Sorensen, A. Yorgancioglu, D. Laune, MACVIA working group

Research output: Contribution to journalReview ArticleResearchpeer-review

19 Citations (Scopus)

Abstract

Background: Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary. Methods: We undertook a 1-year prospective observational study in which 4 210 users and 32 585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale levels <20/100 were categorized as “Low” burden and VAS levels ≥50/100 as “High” burden. Results: Visual analogue scales global measured levels assessing the global control of the allergic disease were significantly associated with allergic multimorbidity. Eight hypothesis-driven patterns were defined based on “Low” and “High” VAS levels. There were <0.2% days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9% days with a Rhinitis High—Asthma Low pattern. There were 1.7% days with a Rhinitis High—Asthma High—Conjunctivitis Low pattern. A novel Rhinitis High—Asthma High—Conjunctivitis High pattern was identified in 2.9% days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels. Conclusions: In a novel approach examining daily symptoms with mobile technology, we found considerable intra-individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of uncontrolled multimorbidity.

Original languageEnglish
Pages (from-to)1622-1631
Number of pages10
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume73
Issue number8
DOIs
Publication statusPublished - 1 Aug 2018

Keywords

  • asthma
  • conjunctivitis
  • multimorbidity
  • rhinitis
  • work productivity

Cite this

Bousquet, J., Devillier, P., Anto, J. M., Bewick, M., Haahtela, T., Arnavielhe, S., ... MACVIA working group (2018). Daily allergic multimorbidity in rhinitis using mobile technology: A novel concept of the MASK study. Allergy: European Journal of Allergy and Clinical Immunology, 73(8), 1622-1631. https://doi.org/10.1111/all.13448
Bousquet, J. ; Devillier, P. ; Anto, J. M. ; Bewick, M. ; Haahtela, T. ; Arnavielhe, S. ; Bedbrook, A. ; Murray, R. ; van Eerd, M. ; Fonseca, J. A. ; Morais Almeida, M. ; Todo Bom, A. ; Menditto, E. ; Passalacqua, G. ; Stellato, C. ; Triggiani, M. ; Ventura, M. T. ; Vezzani, G. ; Annesi-Maesano, I. ; Bourret, R. ; Bosse, I. ; Caimmi, D. ; Cartier, C. ; Demoly, P. ; Just, J. ; Portejoie, F. ; Siroux, V. ; Viart, F. ; Bergmann, K. C. ; Keil, T. ; Klimek, L. ; Mösges, R. ; Pfaar, O. ; Shamai, S. ; Zuberbier, T. ; Mullol, J. ; Valero, A. ; Spranger, O. ; Tomazic, P. V. ; Kowalski, M. L. ; Kuna, P. ; Kupczyk, M. ; Raciborski, F. ; Samolinski, B. ; Toppila-Salmi, S. K. ; Valovirta, E. ; Cruz, A. A. ; Sarquis-Serpa, F. ; da Silva, J. ; Stelmach, R. ; Larenas-Linnemann, D. ; Rodriguez Gonzalez, M. ; Burguete Cabañas, M. T. ; Kvedariene, V. ; Valiulis, A. ; Chavannes, N. H. ; Fokkens, W. J. ; Ryan, D. ; Sheikh, A. ; Bachert, C. ; Hellings, P. W. ; VandenPlas, O. ; Ballardini, N. ; Kull, I. ; Melén, E. ; Westman, M. ; Wickman, M. ; Bindslev-Jensen, C. ; Eller, E. ; Bosnic-Anticevich, S. ; O'Hehir, R. E. ; Agache, I. ; Bieber, T. ; Casale, T. ; Gemicioğlu, B. ; Ivancevich, J. C. ; De Vries, G. ; Sorensen, M. ; Yorgancioglu, A. ; Laune, D. ; MACVIA working group. / Daily allergic multimorbidity in rhinitis using mobile technology : A novel concept of the MASK study. In: Allergy: European Journal of Allergy and Clinical Immunology. 2018 ; Vol. 73, No. 8. pp. 1622-1631.
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title = "Daily allergic multimorbidity in rhinitis using mobile technology: A novel concept of the MASK study",
abstract = "Background: Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary. Methods: We undertook a 1-year prospective observational study in which 4 210 users and 32 585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale levels <20/100 were categorized as “Low” burden and VAS levels ≥50/100 as “High” burden. Results: Visual analogue scales global measured levels assessing the global control of the allergic disease were significantly associated with allergic multimorbidity. Eight hypothesis-driven patterns were defined based on “Low” and “High” VAS levels. There were <0.2{\%} days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9{\%} days with a Rhinitis High—Asthma Low pattern. There were 1.7{\%} days with a Rhinitis High—Asthma High—Conjunctivitis Low pattern. A novel Rhinitis High—Asthma High—Conjunctivitis High pattern was identified in 2.9{\%} days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels. Conclusions: In a novel approach examining daily symptoms with mobile technology, we found considerable intra-individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of uncontrolled multimorbidity.",
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author = "J. Bousquet and P. Devillier and Anto, {J. M.} and M. Bewick and T. Haahtela and S. Arnavielhe and A. Bedbrook and R. Murray and {van Eerd}, M. and Fonseca, {J. A.} and {Morais Almeida}, M. and {Todo Bom}, A. and E. Menditto and G. Passalacqua and C. Stellato and M. Triggiani and Ventura, {M. T.} and G. Vezzani and I. Annesi-Maesano and R. Bourret and I. Bosse and D. Caimmi and C. Cartier and P. Demoly and J. Just and F. Portejoie and V. Siroux and F. Viart and Bergmann, {K. C.} and T. Keil and L. Klimek and R. M{\"o}sges and O. Pfaar and S. Shamai and T. Zuberbier and J. Mullol and A. Valero and O. Spranger and Tomazic, {P. V.} and Kowalski, {M. L.} and P. Kuna and M. Kupczyk and F. Raciborski and B. Samolinski and Toppila-Salmi, {S. K.} and E. Valovirta and Cruz, {A. A.} and F. Sarquis-Serpa and {da Silva}, J. and R. Stelmach and D. Larenas-Linnemann and {Rodriguez Gonzalez}, M. and {Burguete Caba{\~n}as}, {M. T.} and V. Kvedariene and A. Valiulis and Chavannes, {N. H.} and Fokkens, {W. J.} and D. Ryan and A. Sheikh and C. Bachert and Hellings, {P. W.} and O. VandenPlas and N. Ballardini and I. Kull and E. Mel{\'e}n and M. Westman and M. Wickman and C. Bindslev-Jensen and E. Eller and S. Bosnic-Anticevich and O'Hehir, {R. E.} and I. Agache and T. Bieber and T. Casale and B. Gemicioğlu and Ivancevich, {J. C.} and {De Vries}, G. and M. Sorensen and A. Yorgancioglu and D. Laune and {MACVIA working group}",
year = "2018",
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language = "English",
volume = "73",
pages = "1622--1631",
journal = "Allergy",
issn = "0105-4538",
publisher = "Wiley-Blackwell",
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Bousquet, J, Devillier, P, Anto, JM, Bewick, M, Haahtela, T, Arnavielhe, S, Bedbrook, A, Murray, R, van Eerd, M, Fonseca, JA, Morais Almeida, M, Todo Bom, A, Menditto, E, Passalacqua, G, Stellato, C, Triggiani, M, Ventura, MT, Vezzani, G, Annesi-Maesano, I, Bourret, R, Bosse, I, Caimmi, D, Cartier, C, Demoly, P, Just, J, Portejoie, F, Siroux, V, Viart, F, Bergmann, KC, Keil, T, Klimek, L, Mösges, R, Pfaar, O, Shamai, S, Zuberbier, T, Mullol, J, Valero, A, Spranger, O, Tomazic, PV, Kowalski, ML, Kuna, P, Kupczyk, M, Raciborski, F, Samolinski, B, Toppila-Salmi, SK, Valovirta, E, Cruz, AA, Sarquis-Serpa, F, da Silva, J, Stelmach, R, Larenas-Linnemann, D, Rodriguez Gonzalez, M, Burguete Cabañas, MT, Kvedariene, V, Valiulis, A, Chavannes, NH, Fokkens, WJ, Ryan, D, Sheikh, A, Bachert, C, Hellings, PW, VandenPlas, O, Ballardini, N, Kull, I, Melén, E, Westman, M, Wickman, M, Bindslev-Jensen, C, Eller, E, Bosnic-Anticevich, S, O'Hehir, RE, Agache, I, Bieber, T, Casale, T, Gemicioğlu, B, Ivancevich, JC, De Vries, G, Sorensen, M, Yorgancioglu, A, Laune, D & MACVIA working group 2018, 'Daily allergic multimorbidity in rhinitis using mobile technology: A novel concept of the MASK study', Allergy: European Journal of Allergy and Clinical Immunology, vol. 73, no. 8, pp. 1622-1631. https://doi.org/10.1111/all.13448

Daily allergic multimorbidity in rhinitis using mobile technology : A novel concept of the MASK study. / Bousquet, J.; Devillier, P.; Anto, J. M.; Bewick, M.; Haahtela, T.; Arnavielhe, S.; Bedbrook, A.; Murray, R.; van Eerd, M.; Fonseca, J. A.; Morais Almeida, M.; Todo Bom, A.; Menditto, E.; Passalacqua, G.; Stellato, C.; Triggiani, M.; Ventura, M. T.; Vezzani, G.; Annesi-Maesano, I.; Bourret, R.; Bosse, I.; Caimmi, D.; Cartier, C.; Demoly, P.; Just, J.; Portejoie, F.; Siroux, V.; Viart, F.; Bergmann, K. C.; Keil, T.; Klimek, L.; Mösges, R.; Pfaar, O.; Shamai, S.; Zuberbier, T.; Mullol, J.; Valero, A.; Spranger, O.; Tomazic, P. V.; Kowalski, M. L.; Kuna, P.; Kupczyk, M.; Raciborski, F.; Samolinski, B.; Toppila-Salmi, S. K.; Valovirta, E.; Cruz, A. A.; Sarquis-Serpa, F.; da Silva, J.; Stelmach, R.; Larenas-Linnemann, D.; Rodriguez Gonzalez, M.; Burguete Cabañas, M. T.; Kvedariene, V.; Valiulis, A.; Chavannes, N. H.; Fokkens, W. J.; Ryan, D.; Sheikh, A.; Bachert, C.; Hellings, P. W.; VandenPlas, O.; Ballardini, N.; Kull, I.; Melén, E.; Westman, M.; Wickman, M.; Bindslev-Jensen, C.; Eller, E.; Bosnic-Anticevich, S.; O'Hehir, R. E.; Agache, I.; Bieber, T.; Casale, T.; Gemicioğlu, B.; Ivancevich, J. C.; De Vries, G.; Sorensen, M.; Yorgancioglu, A.; Laune, D.; MACVIA working group.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 73, No. 8, 01.08.2018, p. 1622-1631.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Daily allergic multimorbidity in rhinitis using mobile technology

T2 - A novel concept of the MASK study

AU - Bousquet, J.

AU - Devillier, P.

AU - Anto, J. M.

AU - Bewick, M.

AU - Haahtela, T.

AU - Arnavielhe, S.

AU - Bedbrook, A.

AU - Murray, R.

AU - van Eerd, M.

AU - Fonseca, J. A.

AU - Morais Almeida, M.

AU - Todo Bom, A.

AU - Menditto, E.

AU - Passalacqua, G.

AU - Stellato, C.

AU - Triggiani, M.

AU - Ventura, M. T.

AU - Vezzani, G.

AU - Annesi-Maesano, I.

AU - Bourret, R.

AU - Bosse, I.

AU - Caimmi, D.

AU - Cartier, C.

AU - Demoly, P.

AU - Just, J.

AU - Portejoie, F.

AU - Siroux, V.

AU - Viart, F.

AU - Bergmann, K. C.

AU - Keil, T.

AU - Klimek, L.

AU - Mösges, R.

AU - Pfaar, O.

AU - Shamai, S.

AU - Zuberbier, T.

AU - Mullol, J.

AU - Valero, A.

AU - Spranger, O.

AU - Tomazic, P. V.

AU - Kowalski, M. L.

AU - Kuna, P.

AU - Kupczyk, M.

AU - Raciborski, F.

AU - Samolinski, B.

AU - Toppila-Salmi, S. K.

AU - Valovirta, E.

AU - Cruz, A. A.

AU - Sarquis-Serpa, F.

AU - da Silva, J.

AU - Stelmach, R.

AU - Larenas-Linnemann, D.

AU - Rodriguez Gonzalez, M.

AU - Burguete Cabañas, M. T.

AU - Kvedariene, V.

AU - Valiulis, A.

AU - Chavannes, N. H.

AU - Fokkens, W. J.

AU - Ryan, D.

AU - Sheikh, A.

AU - Bachert, C.

AU - Hellings, P. W.

AU - VandenPlas, O.

AU - Ballardini, N.

AU - Kull, I.

AU - Melén, E.

AU - Westman, M.

AU - Wickman, M.

AU - Bindslev-Jensen, C.

AU - Eller, E.

AU - Bosnic-Anticevich, S.

AU - O'Hehir, R. E.

AU - Agache, I.

AU - Bieber, T.

AU - Casale, T.

AU - Gemicioğlu, B.

AU - Ivancevich, J. C.

AU - De Vries, G.

AU - Sorensen, M.

AU - Yorgancioglu, A.

AU - Laune, D.

AU - MACVIA working group

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Background: Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary. Methods: We undertook a 1-year prospective observational study in which 4 210 users and 32 585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale levels <20/100 were categorized as “Low” burden and VAS levels ≥50/100 as “High” burden. Results: Visual analogue scales global measured levels assessing the global control of the allergic disease were significantly associated with allergic multimorbidity. Eight hypothesis-driven patterns were defined based on “Low” and “High” VAS levels. There were <0.2% days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9% days with a Rhinitis High—Asthma Low pattern. There were 1.7% days with a Rhinitis High—Asthma High—Conjunctivitis Low pattern. A novel Rhinitis High—Asthma High—Conjunctivitis High pattern was identified in 2.9% days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels. Conclusions: In a novel approach examining daily symptoms with mobile technology, we found considerable intra-individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of uncontrolled multimorbidity.

AB - Background: Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary. Methods: We undertook a 1-year prospective observational study in which 4 210 users and 32 585 days were monitored in 19 countries. Five visual analogue scales (VAS) assessed the daily burden of the disease (i.e., global evaluation, nose, eyes, asthma and work). Visual analogue scale levels <20/100 were categorized as “Low” burden and VAS levels ≥50/100 as “High” burden. Results: Visual analogue scales global measured levels assessing the global control of the allergic disease were significantly associated with allergic multimorbidity. Eight hypothesis-driven patterns were defined based on “Low” and “High” VAS levels. There were <0.2% days of Rhinitis Low and Asthma High or Conjunctivitis High patterns. There were 5.9% days with a Rhinitis High—Asthma Low pattern. There were 1.7% days with a Rhinitis High—Asthma High—Conjunctivitis Low pattern. A novel Rhinitis High—Asthma High—Conjunctivitis High pattern was identified in 2.9% days and had the greatest impact on uncontrolled VAS global measured and impaired work productivity. Work productivity was significantly correlated with VAS global measured levels. Conclusions: In a novel approach examining daily symptoms with mobile technology, we found considerable intra-individual variability of allergic multimorbidity including a previously unrecognized extreme pattern of uncontrolled multimorbidity.

KW - asthma

KW - conjunctivitis

KW - multimorbidity

KW - rhinitis

KW - work productivity

UR - http://www.scopus.com/inward/record.url?scp=85045929487&partnerID=8YFLogxK

U2 - 10.1111/all.13448

DO - 10.1111/all.13448

M3 - Review Article

VL - 73

SP - 1622

EP - 1631

JO - Allergy

JF - Allergy

SN - 0105-4538

IS - 8

ER -