D-Lactate inhibition of memory in a single trial discrimination avoidance task in the young chick

Kathryn Denise Baker, Thomas Mark Edwards

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9 Citations (Scopus)


L-Lactate is a metabolite possibly able to meet some neuronal energy demands. However, a clear role for L-lactate in behaviour remains elusive. Administration of the inactive isomer D-lactate (1.75 mM; ic), immediately post-training, resulted in a persistent retention loss from 40 min post-training when used in conjuction with a single trial discrimination avoidance task designed for the young chick. Furthermore, 1mM noradrenaline (ic) administered 20 min post-training overcame the retention loss induced by D-lactate. Although not directly demonstrated in the current study, it is plausible that D-lactate inhibited memory processing by competing with L-lactate for uptake into neurons. The time of onset of the retention loss induced by D-lactate is in accord with findings where the action of noradrenaline is inhibited. The successful challenge of D-lactate inhibition by a high concentration of noradrenaline may suggest a relationship by some unidentified mechanism.
Original languageEnglish
Pages (from-to)269 - 276
Number of pages8
JournalNeurobiology of Learning and Memory
Issue number3
Publication statusPublished - 2007

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