TY - JOUR
T1 - Cytotoxicity enhancement in breast cancer cells with carbonate apatite-facilitated intracellular delivery of anti-cancer drugs
AU - Fatemian, Tahereh
AU - Chowdhury, Ezharul Hoque
PY - 2018/2/5
Y1 - 2018/2/5
N2 - Pharmacotherapy as the mainstay in the management of breast cancer has demonstrated various drawbacks, including non-targeted bio distribution and narrow therapeutic and safety windows. Thus, enhancements in pharmacodynamic and pharmacokinetic profiles of the classical anti-cancer drugs could lead to improved efficacy against cancer cells. Therefore, inorganic pH-dependent carbonate apatite (CA) nanoparticles were utilized to efficiently deliver various drugs into cancer cells. Following characterization and various modifications in the structure of CA complexes with different drugs, lifted outcomes were achieved. Markedly, complexing paclitaxel with CA resulted in 20.71 ± 4.34% loading efficiency together with 24.14 ± 2.21% enhancement in cytotoxicity on MCF-7 cells plus superior in vivo anti-tumour efficacy compared to free paclitaxel.
AB - Pharmacotherapy as the mainstay in the management of breast cancer has demonstrated various drawbacks, including non-targeted bio distribution and narrow therapeutic and safety windows. Thus, enhancements in pharmacodynamic and pharmacokinetic profiles of the classical anti-cancer drugs could lead to improved efficacy against cancer cells. Therefore, inorganic pH-dependent carbonate apatite (CA) nanoparticles were utilized to efficiently deliver various drugs into cancer cells. Following characterization and various modifications in the structure of CA complexes with different drugs, lifted outcomes were achieved. Markedly, complexing paclitaxel with CA resulted in 20.71 ± 4.34% loading efficiency together with 24.14 ± 2.21% enhancement in cytotoxicity on MCF-7 cells plus superior in vivo anti-tumour efficacy compared to free paclitaxel.
KW - Breast cancer
KW - Carbonate apatite nanoparticles (NPs)
KW - Cytotoxicity
KW - Paclitaxel
KW - Tumour regression
UR - http://www.scopus.com/inward/record.url?scp=85042478056&partnerID=8YFLogxK
U2 - 10.3390/toxics6010012
DO - 10.3390/toxics6010012
M3 - Article
C2 - 29401738
AN - SCOPUS:85042478056
SN - 2305-6304
VL - 6
JO - Toxics
JF - Toxics
IS - 1
M1 - 12
ER -
