Cytotoxicity enhancement in breast cancer cells with carbonate apatite-facilitated intracellular delivery of anti-cancer drugs

Tahereh Fatemian; Ezharul Hoque Chowdhury

doi:10.3390/toxics6010012

Cytotoxicity enhancement in breast cancer cells with carbonate apatite-facilitated intracellular delivery of anti-cancer drugs

Tahereh Fatemian, Ezharul Hoque Chowdhury

Malaysia Jeffrey Cheah Sch of Med & HS

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Abstract

Pharmacotherapy as the mainstay in the management of breast cancer has demonstrated various drawbacks, including non-targeted bio distribution and narrow therapeutic and safety windows. Thus, enhancements in pharmacodynamic and pharmacokinetic profiles of the classical anti-cancer drugs could lead to improved efficacy against cancer cells. Therefore, inorganic pH-dependent carbonate apatite (CA) nanoparticles were utilized to efficiently deliver various drugs into cancer cells. Following characterization and various modifications in the structure of CA complexes with different drugs, lifted outcomes were achieved. Markedly, complexing paclitaxel with CA resulted in 20.71 ± 4.34% loading efficiency together with 24.14 ± 2.21% enhancement in cytotoxicity on MCF-7 cells plus superior in vivo anti-tumour efficacy compared to free paclitaxel.

Original language	English
Article number	12
Number of pages	17
Journal	Toxics
Volume	6
Issue number	1
DOIs	https://doi.org/10.3390/toxics6010012
Publication status	Published - 5 Feb 2018

Keywords

Breast cancer
Carbonate apatite nanoparticles (NPs)
Cytotoxicity
Paclitaxel
Tumour regression

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/toxics6010012Licence: CC BY

337129100-oaFinal published version, 5.06 MBLicence: CC BY

Cite this

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Cytotoxicity enhancement in breast cancer cells with carbonate apatite-facilitated intracellular delivery of anti-cancer drugs

Abstract

Keywords

UN SDGs

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