Cytotoxicity enhancement in breast cancer cells with carbonate apatite-facilitated intracellular delivery of anti-cancer drugs

Tahereh Fatemian, Ezharul Hoque Chowdhury

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)


Pharmacotherapy as the mainstay in the management of breast cancer has demonstrated various drawbacks, including non-targeted bio distribution and narrow therapeutic and safety windows. Thus, enhancements in pharmacodynamic and pharmacokinetic profiles of the classical anti-cancer drugs could lead to improved efficacy against cancer cells. Therefore, inorganic pH-dependent carbonate apatite (CA) nanoparticles were utilized to efficiently deliver various drugs into cancer cells. Following characterization and various modifications in the structure of CA complexes with different drugs, lifted outcomes were achieved. Markedly, complexing paclitaxel with CA resulted in 20.71 ± 4.34% loading efficiency together with 24.14 ± 2.21% enhancement in cytotoxicity on MCF-7 cells plus superior in vivo anti-tumour efficacy compared to free paclitaxel.

Original languageEnglish
Article number12
Number of pages17
Issue number1
Publication statusPublished - 5 Feb 2018


  • Breast cancer
  • Carbonate apatite nanoparticles (NPs)
  • Cytotoxicity
  • Paclitaxel
  • Tumour regression

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