Cytotoxic labdane diterpenes, norlabdane diterpenes and bis-labdanic diterpenes from the Zingiberaceae: A systematic review

Kelvin Jianmin Voon, Yasodha Sivasothy, Usha Sundralingam, Aicha Lalmahomed, Asly Poh-Tze Goh

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)


Over the years, labdane diterpenes, norlabdane diterpenes, and bis-labdanic diterpenes with cytotoxic activities have been identified across various families in the plant kingdom including the Zingiberaceae. The present review discusses the distribution of these labdane-type diterpenes within the Zingiberaceae; their extraction, isolation, and characterization from the respective Zingiberaceae species; the structural similarities and differences within each group and between the different groups of the labdane-type diterpenes; and their cytotoxic activities against breast, cervical, liver, colorectal, pancreatic, lung and prostate cancer cell lines. The review will also provide insight into how the cytotoxic activities of the labdane-type diterpenes are influenced by their structural features.

Original languageEnglish
Article number1517
Number of pages58
Issue number12
Publication statusPublished - Dec 2022


  • bis-labdanic diterpenes
  • cytotoxicity
  • labdane diterpenes
  • norlabdane diterpenes
  • Zingiberaceae

Cite this