Cytotoxic factor influencing acquired antimicrobial resistance in Pseudomonas aeruginosa

Dinesh Subedi, Ajay Kumar Vijay, Scott A. Rice, Mark Willcox

Research output: Contribution to journalReview ArticleResearchpeer-review


The Gram-negative opportunistic bacterium Pseudomonas aeruginosa is associated with different types of human infections and because of emerging multidrug-resistant strains, these infections are of major global public health concern. Certain strains possess a unique cytotoxic effector protein ExoU, which contributes to the fitness of this organism in different ecological niches and is associated with acquired antibiotic resistance. This article summarises the current knowledge of the exoU gene in P. aeruginosa, including genetics, distribution in strains from different locations and association with antibiotic resistance. Understanding of this effector protein may have important implications for the understanding of pathogenesis and antimicrobial resistance in P. aeruginosa infections.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalMicrobiology Australia
Issue number4
Publication statusPublished - 29 Oct 2019
Externally publishedYes

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