Early studies reported cytomegalovirus (CMV) pneumonitis as a risk factor for development of bronchiolitis obliterans syndrome (BOS) following lung transplantation. While improvements in antiviral prophylaxis have resulted in a decreased incidence of CMV pneumonitis, molecular diagnostic techniques allow diagnosis of subclinical CMV replication in the allograft.
Paraskeva, M., Bailey, M., Levvey, B., Griffiths, A., Kotsimbos, T. C., Williams, T., Snell, G., & Westall, G. (2011). Cytomegalovirus replication within the lung allograft is associated with bronchiolitis obliterans syndrome. American Journal of Transplantation, 11(10), 2190 - 2196. https://doi.org/10.1111/j.1600-6143.2011.03663.x