Cytokine Receptors and Their Ligands

U. Dhagat; T.L. Nero; W.L. Kan; T.R. Hercus; S.E. Broughton; N.A. De Weerd; B.J. Jenkins; A. Mansell; M.A. Guthridge; P.J. Hertzog; A.F. Lopez; M.W. Parker

doi:10.1016/B978-0-12-394447-4.30002-5

Cytokine Receptors and Their Ligands

U. Dhagat
, T.L. Nero
, W.L. Kan
, T.R. Hercus
, S.E. Broughton
, N.A. De Weerd
, B.J. Jenkins
, A. Mansell
, M.A. Guthridge
, P.J. Hertzog
, A.F. Lopez
, M.W. Parker

Research output: Chapter in Book/Report/Conference proceeding › Encyclopaedia / Dictionary Entry › Other › peer-review

Abstract

Cytokines act through their membrane-bound receptors to transmit a variety of signals including cell survival, proliferation, differentiation, and functional activity. Cytokine receptors are a conserved family of about 40 members that includes the receptors for hormones, interleukins, interferons, and colony-stimulating factors. Abnormal cytokine levels or aberrations in their signaling pathways can lead to a variety of diseases including cancers and inflammatory conditions reflecting their importance in normal hematopoiesis and immunity. Determination of the three-dimensional atomic structures of cytokines and their receptors has provided detailed insights into how cytokines transmit biological signals across cell membranes.

Original language	English
Title of host publication	Encyclopedia of Cell Biology
Subtitle of host publication	Functional Cell Biology
Editors	Ralph A Bradshaw, Philip D Stahl
Place of Publication	Waltham MA USA
Publisher	Elsevier
Pages	22-36
Number of pages	15
Volume	3
ISBN (Electronic)	9780123944474
ISBN (Print)	9780123947963
DOIs	https://doi.org/10.1016/B978-0-12-394447-4.30002-5
Publication status	Published - 1 Jan 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Arthritis
Asthma
Cancer
Cytokine receptors
Cytokines
Growth factors
Hematopoiesis
Immunity
Inflammation
Interferons
Interleukins
Leukemia
Membrane signaling
Myeloid cells
Receptors

Access to Document

10.1016/B978-0-12-394447-4.30002-5

Cite this

Dhagat, U., Nero, T. L., Kan, W. L., Hercus, T. R., Broughton, S. E., De Weerd, N. A., Jenkins, B. J., Mansell, A., Guthridge, M. A., Hertzog, P. J., Lopez, A. F., & Parker, M. W. (2015). Cytokine Receptors and Their Ligands. In R. A. Bradshaw, & P. D. Stahl (Eds.), Encyclopedia of Cell Biology: Functional Cell Biology (Vol. 3, pp. 22-36). Elsevier. https://doi.org/10.1016/B978-0-12-394447-4.30002-5

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title = "Cytokine Receptors and Their Ligands",

abstract = "Cytokines act through their membrane-bound receptors to transmit a variety of signals including cell survival, proliferation, differentiation, and functional activity. Cytokine receptors are a conserved family of about 40 members that includes the receptors for hormones, interleukins, interferons, and colony-stimulating factors. Abnormal cytokine levels or aberrations in their signaling pathways can lead to a variety of diseases including cancers and inflammatory conditions reflecting their importance in normal hematopoiesis and immunity. Determination of the three-dimensional atomic structures of cytokines and their receptors has provided detailed insights into how cytokines transmit biological signals across cell membranes.",

keywords = "Arthritis, Asthma, Cancer, Cytokine receptors, Cytokines, Growth factors, Hematopoiesis, Immunity, Inflammation, Interferons, Interleukins, Leukemia, Membrane signaling, Myeloid cells, Receptors",

author = "U. Dhagat and T.L. Nero and W.L. Kan and T.R. Hercus and S.E. Broughton and \{De Weerd\}, N.A. and B.J. Jenkins and A. Mansell and M.A. Guthridge and P.J. Hertzog and A.F. Lopez and M.W. Parker",

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Dhagat, U, Nero, TL, Kan, WL, Hercus, TR, Broughton, SE, De Weerd, NA , Jenkins, BJ , Mansell, A, Guthridge, MA, Hertzog, PJ, Lopez, AF & Parker, MW 2015, Cytokine Receptors and Their Ligands. in RA Bradshaw & PD Stahl (eds), Encyclopedia of Cell Biology: Functional Cell Biology. vol. 3, Elsevier, Waltham MA USA, pp. 22-36. https://doi.org/10.1016/B978-0-12-394447-4.30002-5

TY - CHAP

T1 - Cytokine Receptors and Their Ligands

AU - Dhagat, U.

AU - Nero, T.L.

AU - Kan, W.L.

AU - Hercus, T.R.

AU - Broughton, S.E.

AU - De Weerd, N.A.

AU - Jenkins, B.J.

AU - Mansell, A.

AU - Guthridge, M.A.

AU - Hertzog, P.J.

AU - Lopez, A.F.

AU - Parker, M.W.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Cytokines act through their membrane-bound receptors to transmit a variety of signals including cell survival, proliferation, differentiation, and functional activity. Cytokine receptors are a conserved family of about 40 members that includes the receptors for hormones, interleukins, interferons, and colony-stimulating factors. Abnormal cytokine levels or aberrations in their signaling pathways can lead to a variety of diseases including cancers and inflammatory conditions reflecting their importance in normal hematopoiesis and immunity. Determination of the three-dimensional atomic structures of cytokines and their receptors has provided detailed insights into how cytokines transmit biological signals across cell membranes.

AB - Cytokines act through their membrane-bound receptors to transmit a variety of signals including cell survival, proliferation, differentiation, and functional activity. Cytokine receptors are a conserved family of about 40 members that includes the receptors for hormones, interleukins, interferons, and colony-stimulating factors. Abnormal cytokine levels or aberrations in their signaling pathways can lead to a variety of diseases including cancers and inflammatory conditions reflecting their importance in normal hematopoiesis and immunity. Determination of the three-dimensional atomic structures of cytokines and their receptors has provided detailed insights into how cytokines transmit biological signals across cell membranes.

KW - Arthritis

KW - Asthma

KW - Cancer

KW - Cytokine receptors

KW - Cytokines

KW - Growth factors

KW - Hematopoiesis

KW - Immunity

KW - Inflammation

KW - Interferons

KW - Interleukins

KW - Leukemia

KW - Membrane signaling

KW - Myeloid cells

KW - Receptors

UR - https://www.scopus.com/pages/publications/85042797724

U2 - 10.1016/B978-0-12-394447-4.30002-5

DO - 10.1016/B978-0-12-394447-4.30002-5

M3 - Encyclopaedia / Dictionary Entry

AN - SCOPUS:85042797724

SN - 9780123947963

VL - 3

SP - 22

EP - 36

BT - Encyclopedia of Cell Biology

A2 - Bradshaw, Ralph A

A2 - Stahl, Philip D

PB - Elsevier

CY - Waltham MA USA

ER -

Cytokine Receptors and Their Ligands

Abstract

UN SDGs

Keywords

Access to Document

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Research output

Cytokine Receptors and Their Ligands

Cite this