Cytokine Receptors and Their Ligands

U. Dhagat, T.L. Nero, W.L. Kan, T.R. Hercus, S.E. Broughton, N.A. De Weerd, B.J. Jenkins, A. Mansell, M.A. Guthridge, P.J. Hertzog, A.F. Lopez, M.W. Parker

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review

Abstract

Cytokines act through their membrane-bound receptors to transmit a variety of signals including cell survival, proliferation, differentiation, and functional activity. Cytokine receptors are a conserved family of about 40 members that includes the receptors for hormones, interleukins, interferons, and colony-stimulating factors. Abnormal cytokine levels or aberrations in their signaling pathways can lead to a variety of diseases including cancers and inflammatory conditions reflecting their importance in normal hematopoiesis and immunity. Determination of the three-dimensional atomic structures of cytokines and their receptors has provided detailed insights into how cytokines transmit biological signals across cell membranes.

Original languageEnglish
Title of host publicationEncyclopedia of Cell Biology
Subtitle of host publicationFunctional Cell Biology
EditorsRalph A Bradshaw, Philip D Stahl
Place of PublicationWaltham MA USA
PublisherElsevier
Pages22-36
Number of pages15
Volume3
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • Arthritis
  • Asthma
  • Cancer
  • Cytokine receptors
  • Cytokines
  • Growth factors
  • Hematopoiesis
  • Immunity
  • Inflammation
  • Interferons
  • Interleukins
  • Leukemia
  • Membrane signaling
  • Myeloid cells
  • Receptors

Cite this

Dhagat, U., Nero, T. L., Kan, W. L., Hercus, T. R., Broughton, S. E., De Weerd, N. A., Jenkins, B. J., Mansell, A., Guthridge, M. A., Hertzog, P. J., Lopez, A. F., & Parker, M. W. (2015). Cytokine Receptors and Their Ligands. In R. A. Bradshaw, & P. D. Stahl (Eds.), Encyclopedia of Cell Biology: Functional Cell Biology (Vol. 3, pp. 22-36). Elsevier. https://doi.org/10.1016/B978-0-12-394447-4.30002-5