Objectives. To study the role of cytokines on adhesion molecule expression and binding of activated T cells to synovial type B cells. Methods. Adhesion molecule expression was examined by immunofluorescence and adhesion of 51Cr-labeled T cells to the synovial cells determined. Results. Tumor necrosis factor alpha/interferon gamma (TNFα/IFN-γ) and interleukin 1 alpha (IL-1α)/IFN-γ enhanced adhesion molecule expression and the adhesion of T cells to synovial cells. Anti-intercellular adhesion molecule I blocked adhesion of T cells to TNFα/IFN-γ and IL-1α/IFN-γ stimulated synovial cells while an antibody to CD61 blocked adhesion to IL-1α/IFN-γ stimulated cells. Conclusions. The interaction of leukocytes with adhesion molecules on synovial cells may play a role in recruitment of these cells to an inflammatory site.
|Number of pages||7|
|Journal||The Journal of Rheumatology|
|Publication status||Published - 1994|
- ADHESION MOLECULES