Cytokine induction of adhesion molecules on synovial type B cells

F. M. Cicuttini, M. Martin, A. W. Boyd

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13 Citations (Scopus)

Abstract

Objectives. To study the role of cytokines on adhesion molecule expression and binding of activated T cells to synovial type B cells. Methods. Adhesion molecule expression was examined by immunofluorescence and adhesion of 51Cr-labeled T cells to the synovial cells determined. Results. Tumor necrosis factor alpha/interferon gamma (TNFα/IFN-γ) and interleukin 1 alpha (IL-1α)/IFN-γ enhanced adhesion molecule expression and the adhesion of T cells to synovial cells. Anti-intercellular adhesion molecule I blocked adhesion of T cells to TNFα/IFN-γ and IL-1α/IFN-γ stimulated synovial cells while an antibody to CD61 blocked adhesion to IL-1α/IFN-γ stimulated cells. Conclusions. The interaction of leukocytes with adhesion molecules on synovial cells may play a role in recruitment of these cells to an inflammatory site.

Original languageEnglish
Pages (from-to)406-412
Number of pages7
JournalThe Journal of Rheumatology
Volume21
Issue number3
Publication statusPublished - 1994
Externally publishedYes

Keywords

  • ADHESION MOLECULES
  • ARTHRITIS
  • CYTOKINES
  • LYMPHOCYTES

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