Cysteine and resistance to oxidative stress: implications for virulence and antibiotic resistance

Alexandra Tikhomirova; Mohammad M. Rahman; Stephen P. Kidd; Richard L. Fererro; Anna Roujeinikova

doi:10.1016/j.tim.2023.06.010

Cysteine and resistance to oxidative stress: implications for virulence and antibiotic resistance

Alexandra Tikhomirova, Mohammad M. Rahman, Stephen P. Kidd, Richard L. Fererro, Anna Roujeinikova

Research output: Contribution to journal › Review Article › Research › peer-review

51 Citations (Scopus)

Abstract

Reactive oxygen species (ROS), including the superoxide radical anion (O₂^•–), hydrogen peroxide (H₂O₂), and the hydroxyl radical (^•HO), are inherent components of bacterial metabolism in an aerobic environment. Bacteria also encounter exogenous ROS, such as those produced by the host cells during the respiratory burst. As ROS have the capacity to damage bacterial DNA, proteins, and lipids, detoxification of ROS is critical for bacterial survival. It has been recently recognised that low-molecular-weight (LMW) thiols play a central role in this process. Here, we review the emerging role of cysteine in bacterial resistance to ROS with a link to broader elements of bacterial lifestyle closely associated with cysteine-mediated oxidative stress response, including virulence and antibiotic resistance.

Original language	English
Pages (from-to)	93-104
Number of pages	12
Journal	Trends in Microbiology
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.tim.2023.06.010
Publication status	Published - Jan 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

antibiotic resistance
cysteine
oxidative stress
reactive oxygen species
virulence

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10.1016/j.tim.2023.06.010

501373465-oaAccepted author manuscript, 1.42 MBLicence: CC BY-NC-ND

Cite this

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title = "Cysteine and resistance to oxidative stress: implications for virulence and antibiotic resistance",

abstract = "Reactive oxygen species (ROS), including the superoxide radical anion (O2•–), hydrogen peroxide (H2O2), and the hydroxyl radical (•HO), are inherent components of bacterial metabolism in an aerobic environment. Bacteria also encounter exogenous ROS, such as those produced by the host cells during the respiratory burst. As ROS have the capacity to damage bacterial DNA, proteins, and lipids, detoxification of ROS is critical for bacterial survival. It has been recently recognised that low-molecular-weight (LMW) thiols play a central role in this process. Here, we review the emerging role of cysteine in bacterial resistance to ROS with a link to broader elements of bacterial lifestyle closely associated with cysteine-mediated oxidative stress response, including virulence and antibiotic resistance.",

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author = "Alexandra Tikhomirova and Rahman, \{Mohammad M.\} and Kidd, \{Stephen P.\} and Fererro, \{Richard L.\} and Anna Roujeinikova",

note = "Funding Information: This work was supported by the National Health and Medical Research Council (NHMRC) Ideas grant 2011010 to A.R. and R.L.F. Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

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T1 - Cysteine and resistance to oxidative stress

T2 - implications for virulence and antibiotic resistance

AU - Tikhomirova, Alexandra

AU - Rahman, Mohammad M.

AU - Kidd, Stephen P.

AU - Fererro, Richard L.

AU - Roujeinikova, Anna

PY - 2024/1

Y1 - 2024/1

N2 - Reactive oxygen species (ROS), including the superoxide radical anion (O2•–), hydrogen peroxide (H2O2), and the hydroxyl radical (•HO), are inherent components of bacterial metabolism in an aerobic environment. Bacteria also encounter exogenous ROS, such as those produced by the host cells during the respiratory burst. As ROS have the capacity to damage bacterial DNA, proteins, and lipids, detoxification of ROS is critical for bacterial survival. It has been recently recognised that low-molecular-weight (LMW) thiols play a central role in this process. Here, we review the emerging role of cysteine in bacterial resistance to ROS with a link to broader elements of bacterial lifestyle closely associated with cysteine-mediated oxidative stress response, including virulence and antibiotic resistance.

AB - Reactive oxygen species (ROS), including the superoxide radical anion (O2•–), hydrogen peroxide (H2O2), and the hydroxyl radical (•HO), are inherent components of bacterial metabolism in an aerobic environment. Bacteria also encounter exogenous ROS, such as those produced by the host cells during the respiratory burst. As ROS have the capacity to damage bacterial DNA, proteins, and lipids, detoxification of ROS is critical for bacterial survival. It has been recently recognised that low-molecular-weight (LMW) thiols play a central role in this process. Here, we review the emerging role of cysteine in bacterial resistance to ROS with a link to broader elements of bacterial lifestyle closely associated with cysteine-mediated oxidative stress response, including virulence and antibiotic resistance.

KW - antibiotic resistance

KW - cysteine

KW - oxidative stress

KW - reactive oxygen species

KW - virulence

UR - https://www.scopus.com/pages/publications/85165284607

U2 - 10.1016/j.tim.2023.06.010

DO - 10.1016/j.tim.2023.06.010

M3 - Review Article

C2 - 37479622

AN - SCOPUS:85165284607

SN - 0966-842X

VL - 32

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EP - 104

JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 1

ER -

Cysteine and resistance to oxidative stress: implications for virulence and antibiotic resistance

Abstract

UN SDGs

Keywords

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