TY - JOUR
T1 - Cysteine and resistance to oxidative stress
T2 - implications for virulence and antibiotic resistance
AU - Tikhomirova, Alexandra
AU - Rahman, Mohammad M.
AU - Kidd, Stephen P.
AU - Fererro, Richard L.
AU - Roujeinikova, Anna
N1 - Funding Information:
This work was supported by the National Health and Medical Research Council (NHMRC) Ideas grant 2011010 to A.R. and R.L.F.
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2024/1
Y1 - 2024/1
N2 - Reactive oxygen species (ROS), including the superoxide radical anion (O2•–), hydrogen peroxide (H2O2), and the hydroxyl radical (•HO), are inherent components of bacterial metabolism in an aerobic environment. Bacteria also encounter exogenous ROS, such as those produced by the host cells during the respiratory burst. As ROS have the capacity to damage bacterial DNA, proteins, and lipids, detoxification of ROS is critical for bacterial survival. It has been recently recognised that low-molecular-weight (LMW) thiols play a central role in this process. Here, we review the emerging role of cysteine in bacterial resistance to ROS with a link to broader elements of bacterial lifestyle closely associated with cysteine-mediated oxidative stress response, including virulence and antibiotic resistance.
AB - Reactive oxygen species (ROS), including the superoxide radical anion (O2•–), hydrogen peroxide (H2O2), and the hydroxyl radical (•HO), are inherent components of bacterial metabolism in an aerobic environment. Bacteria also encounter exogenous ROS, such as those produced by the host cells during the respiratory burst. As ROS have the capacity to damage bacterial DNA, proteins, and lipids, detoxification of ROS is critical for bacterial survival. It has been recently recognised that low-molecular-weight (LMW) thiols play a central role in this process. Here, we review the emerging role of cysteine in bacterial resistance to ROS with a link to broader elements of bacterial lifestyle closely associated with cysteine-mediated oxidative stress response, including virulence and antibiotic resistance.
KW - antibiotic resistance
KW - cysteine
KW - oxidative stress
KW - reactive oxygen species
KW - virulence
UR - http://www.scopus.com/inward/record.url?scp=85165284607&partnerID=8YFLogxK
U2 - 10.1016/j.tim.2023.06.010
DO - 10.1016/j.tim.2023.06.010
M3 - Review Article
C2 - 37479622
AN - SCOPUS:85165284607
SN - 0966-842X
VL - 32
SP - 93
EP - 104
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 1
ER -
