Cystatin C estimated glomerular filtration rate and all-cause and cardiovascular disease mortality risk in the general population: AusDiab study

Elizabeth L.M. Barr, Anne Reutens, Dianna Magliano, Rory Wolfe, Zhong X Lu, Ken A Sikaris, Stephanie K. Tanamas, Robert Atkins, Steve Chadban, Jonathan E. Shaw, Kevan R Polkinghorne

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Aims: Uncertainties about the role of cystatin C based estimated glomerular filtration rate (eGFR) in the prediction of cardiovascular disease (CVD) beyond traditional CVD risk factors remain. We assessed contributions of eGFR to CVD and mortality in the general population. Methods: Using 14 year follow-up data on 9353 adults without a reported history of CVD from the Australian Diabetes, Obesity and Lifestyle study, we assessed the contributions of eGFR (assessed by cystatin C (eGFRcysC) and serum creatinine (eGFRcr )) and albuminuria (uACR) to total and CVD mortality. Results: After adjusting for age, sex, CVD risk factors and uACR, compared to an eGFRcysC >90 ml/min per 1.73m2, eGFRcysC <60 ml/min per 1.7 3m2 was associated with 56% and 73% increases in the risks for all-cause and CVD mortality, respectively. The respective changes for the c-statistic when eGFRcysC was added to a risk prediction model were 0.003 (95% CI: 0.001 to 0.005) and 0.002 (-0.001 to 0.006). The net proportion of non-events assigned a lower risk category significantly improved with the addition of eGFR (non-event NRI eGFRcr: 1.0%, and eGFRcysC:1.5%) for all-cause mortality, but for CVD mortality, improvements were only significant when eGFR was combined with uACR. The net proportion of events assigned a higher risk category was not significantly improved. Conclusion: In our community-based cohort, reduced eGFRcysC was associated with all-cause and CVD mortality. The addition of CKD measures to risk prediction models improved overall risk stratification among those at low risk as opposed to those at high baseline risk of mortality. This article is protected by copyright. All rights reserved.
Original languageEnglish
Pages (from-to)243-250
Number of pages8
JournalNephrology
Volume22
Issue number3
DOIs
Publication statusPublished - 1 Mar 2017

Keywords

  • cardiovascular diseases
  • cystatin C
  • estimated glomerular filtration rate
  • mortality
  • risk factors

Cite this

@article{c178a03d98e1426cb38d47b3245e0b63,
title = "Cystatin C estimated glomerular filtration rate and all-cause and cardiovascular disease mortality risk in the general population: AusDiab study",
abstract = "Aims: Uncertainties about the role of cystatin C based estimated glomerular filtration rate (eGFR) in the prediction of cardiovascular disease (CVD) beyond traditional CVD risk factors remain. We assessed contributions of eGFR to CVD and mortality in the general population. Methods: Using 14 year follow-up data on 9353 adults without a reported history of CVD from the Australian Diabetes, Obesity and Lifestyle study, we assessed the contributions of eGFR (assessed by cystatin C (eGFRcysC) and serum creatinine (eGFRcr )) and albuminuria (uACR) to total and CVD mortality. Results: After adjusting for age, sex, CVD risk factors and uACR, compared to an eGFRcysC >90 ml/min per 1.73m2, eGFRcysC <60 ml/min per 1.7 3m2 was associated with 56{\%} and 73{\%} increases in the risks for all-cause and CVD mortality, respectively. The respective changes for the c-statistic when eGFRcysC was added to a risk prediction model were 0.003 (95{\%} CI: 0.001 to 0.005) and 0.002 (-0.001 to 0.006). The net proportion of non-events assigned a lower risk category significantly improved with the addition of eGFR (non-event NRI eGFRcr: 1.0{\%}, and eGFRcysC:1.5{\%}) for all-cause mortality, but for CVD mortality, improvements were only significant when eGFR was combined with uACR. The net proportion of events assigned a higher risk category was not significantly improved. Conclusion: In our community-based cohort, reduced eGFRcysC was associated with all-cause and CVD mortality. The addition of CKD measures to risk prediction models improved overall risk stratification among those at low risk as opposed to those at high baseline risk of mortality. This article is protected by copyright. All rights reserved.",
keywords = "cardiovascular diseases, cystatin C, estimated glomerular filtration rate, mortality, risk factors",
author = "Barr, {Elizabeth L.M.} and Anne Reutens and Dianna Magliano and Rory Wolfe and Lu, {Zhong X} and Sikaris, {Ken A} and Tanamas, {Stephanie K.} and Robert Atkins and Steve Chadban and Shaw, {Jonathan E.} and Polkinghorne, {Kevan R}",
year = "2017",
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language = "English",
volume = "22",
pages = "243--250",
journal = "Nephrology",
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}

Cystatin C estimated glomerular filtration rate and all-cause and cardiovascular disease mortality risk in the general population : AusDiab study. / Barr, Elizabeth L.M.; Reutens, Anne; Magliano, Dianna; Wolfe, Rory; Lu, Zhong X; Sikaris, Ken A; Tanamas, Stephanie K.; Atkins, Robert ; Chadban, Steve; Shaw, Jonathan E.; Polkinghorne, Kevan R.

In: Nephrology, Vol. 22, No. 3, 01.03.2017, p. 243-250.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Cystatin C estimated glomerular filtration rate and all-cause and cardiovascular disease mortality risk in the general population

T2 - AusDiab study

AU - Barr, Elizabeth L.M.

AU - Reutens, Anne

AU - Magliano, Dianna

AU - Wolfe, Rory

AU - Lu, Zhong X

AU - Sikaris, Ken A

AU - Tanamas, Stephanie K.

AU - Atkins, Robert

AU - Chadban, Steve

AU - Shaw, Jonathan E.

AU - Polkinghorne, Kevan R

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Aims: Uncertainties about the role of cystatin C based estimated glomerular filtration rate (eGFR) in the prediction of cardiovascular disease (CVD) beyond traditional CVD risk factors remain. We assessed contributions of eGFR to CVD and mortality in the general population. Methods: Using 14 year follow-up data on 9353 adults without a reported history of CVD from the Australian Diabetes, Obesity and Lifestyle study, we assessed the contributions of eGFR (assessed by cystatin C (eGFRcysC) and serum creatinine (eGFRcr )) and albuminuria (uACR) to total and CVD mortality. Results: After adjusting for age, sex, CVD risk factors and uACR, compared to an eGFRcysC >90 ml/min per 1.73m2, eGFRcysC <60 ml/min per 1.7 3m2 was associated with 56% and 73% increases in the risks for all-cause and CVD mortality, respectively. The respective changes for the c-statistic when eGFRcysC was added to a risk prediction model were 0.003 (95% CI: 0.001 to 0.005) and 0.002 (-0.001 to 0.006). The net proportion of non-events assigned a lower risk category significantly improved with the addition of eGFR (non-event NRI eGFRcr: 1.0%, and eGFRcysC:1.5%) for all-cause mortality, but for CVD mortality, improvements were only significant when eGFR was combined with uACR. The net proportion of events assigned a higher risk category was not significantly improved. Conclusion: In our community-based cohort, reduced eGFRcysC was associated with all-cause and CVD mortality. The addition of CKD measures to risk prediction models improved overall risk stratification among those at low risk as opposed to those at high baseline risk of mortality. This article is protected by copyright. All rights reserved.

AB - Aims: Uncertainties about the role of cystatin C based estimated glomerular filtration rate (eGFR) in the prediction of cardiovascular disease (CVD) beyond traditional CVD risk factors remain. We assessed contributions of eGFR to CVD and mortality in the general population. Methods: Using 14 year follow-up data on 9353 adults without a reported history of CVD from the Australian Diabetes, Obesity and Lifestyle study, we assessed the contributions of eGFR (assessed by cystatin C (eGFRcysC) and serum creatinine (eGFRcr )) and albuminuria (uACR) to total and CVD mortality. Results: After adjusting for age, sex, CVD risk factors and uACR, compared to an eGFRcysC >90 ml/min per 1.73m2, eGFRcysC <60 ml/min per 1.7 3m2 was associated with 56% and 73% increases in the risks for all-cause and CVD mortality, respectively. The respective changes for the c-statistic when eGFRcysC was added to a risk prediction model were 0.003 (95% CI: 0.001 to 0.005) and 0.002 (-0.001 to 0.006). The net proportion of non-events assigned a lower risk category significantly improved with the addition of eGFR (non-event NRI eGFRcr: 1.0%, and eGFRcysC:1.5%) for all-cause mortality, but for CVD mortality, improvements were only significant when eGFR was combined with uACR. The net proportion of events assigned a higher risk category was not significantly improved. Conclusion: In our community-based cohort, reduced eGFRcysC was associated with all-cause and CVD mortality. The addition of CKD measures to risk prediction models improved overall risk stratification among those at low risk as opposed to those at high baseline risk of mortality. This article is protected by copyright. All rights reserved.

KW - cardiovascular diseases

KW - cystatin C

KW - estimated glomerular filtration rate

KW - mortality

KW - risk factors

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U2 - 10.1111/nep.12759

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