Cyrene: A bio-based sustainable solvent for organic synthesis

Dickson Kong; Anton V. Dolzhenko

doi:10.1016/j.scp.2021.100591

Cyrene: A bio-based sustainable solvent for organic synthesis

Dickson Kong, Anton V. Dolzhenko

Malaysia Sch of Pharmacy

Research output: Contribution to journal › Article › Research › peer-review

31 Citations (Scopus)

Abstract

Cyrene (dihydrolevoglucosenone) is a green dipolar aprotic solvent prepared by pyrolysis of cellulose-containing biomass. Cyrene possesses a beneficial occupational health and safety profile combined with good biodegradability without NO_x or SO_x production. Since 2014, when Cyrene was for the first time introduced as a green solvent, it has attracted much attention in different fields. In this review, we discuss organic reactions, for which Cyrene was employed to play the role of medium. Significant progress was achieved in the replacement of conventional aprotic solvents by Cyrene as a safe and sustainable alternative. Cyrene demonstrated to be an effective medium for diverse chemical transformations, from carbon-carbon coupling reactions to bio-catalyzed processes and polymerization. The applications of Cyrene as a co-solvent (e.g. in form of aqueous solutions) for organic synthesis are also discussed.

Original language	English
Article number	100591
Number of pages	16
Journal	Sustainable Chemistry and Pharmacy
Volume	25
DOIs	https://doi.org/10.1016/j.scp.2021.100591
Publication status	Published - Apr 2022

Keywords

Bio-based solvent
Cyrene
Dihydrolevoglucosenone
Green solvent
Sustainable organic synthesis

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10.1016/j.scp.2021.100591

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title = "Cyrene: A bio-based sustainable solvent for organic synthesis",

abstract = "Cyrene (dihydrolevoglucosenone) is a green dipolar aprotic solvent prepared by pyrolysis of cellulose-containing biomass. Cyrene possesses a beneficial occupational health and safety profile combined with good biodegradability without NOx or SOx production. Since 2014, when Cyrene was for the first time introduced as a green solvent, it has attracted much attention in different fields. In this review, we discuss organic reactions, for which Cyrene was employed to play the role of medium. Significant progress was achieved in the replacement of conventional aprotic solvents by Cyrene as a safe and sustainable alternative. Cyrene demonstrated to be an effective medium for diverse chemical transformations, from carbon-carbon coupling reactions to bio-catalyzed processes and polymerization. The applications of Cyrene as a co-solvent (e.g. in form of aqueous solutions) for organic synthesis are also discussed.",

keywords = "Bio-based solvent, Cyrene, Dihydrolevoglucosenone, Green solvent, Sustainable organic synthesis",

author = "Dickson Kong and Dolzhenko, {Anton V.}",

note = "Funding Information: This research was funded by the Ministry of Higher Education, Malaysia under the Fundamental Research Grant Scheme, grant no. FRGS/1/2020/STG04/MUSM/02/2 . Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

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doi = "10.1016/j.scp.2021.100591",

language = "English",

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T2 - A bio-based sustainable solvent for organic synthesis

AU - Kong, Dickson

AU - Dolzhenko, Anton V.

N1 - Funding Information: This research was funded by the Ministry of Higher Education, Malaysia under the Fundamental Research Grant Scheme, grant no. FRGS/1/2020/STG04/MUSM/02/2 . Publisher Copyright: © 2021 Elsevier B.V.

PY - 2022/4

Y1 - 2022/4

N2 - Cyrene (dihydrolevoglucosenone) is a green dipolar aprotic solvent prepared by pyrolysis of cellulose-containing biomass. Cyrene possesses a beneficial occupational health and safety profile combined with good biodegradability without NOx or SOx production. Since 2014, when Cyrene was for the first time introduced as a green solvent, it has attracted much attention in different fields. In this review, we discuss organic reactions, for which Cyrene was employed to play the role of medium. Significant progress was achieved in the replacement of conventional aprotic solvents by Cyrene as a safe and sustainable alternative. Cyrene demonstrated to be an effective medium for diverse chemical transformations, from carbon-carbon coupling reactions to bio-catalyzed processes and polymerization. The applications of Cyrene as a co-solvent (e.g. in form of aqueous solutions) for organic synthesis are also discussed.

AB - Cyrene (dihydrolevoglucosenone) is a green dipolar aprotic solvent prepared by pyrolysis of cellulose-containing biomass. Cyrene possesses a beneficial occupational health and safety profile combined with good biodegradability without NOx or SOx production. Since 2014, when Cyrene was for the first time introduced as a green solvent, it has attracted much attention in different fields. In this review, we discuss organic reactions, for which Cyrene was employed to play the role of medium. Significant progress was achieved in the replacement of conventional aprotic solvents by Cyrene as a safe and sustainable alternative. Cyrene demonstrated to be an effective medium for diverse chemical transformations, from carbon-carbon coupling reactions to bio-catalyzed processes and polymerization. The applications of Cyrene as a co-solvent (e.g. in form of aqueous solutions) for organic synthesis are also discussed.

KW - Bio-based solvent

KW - Cyrene

KW - Dihydrolevoglucosenone

KW - Green solvent

KW - Sustainable organic synthesis

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DO - 10.1016/j.scp.2021.100591

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VL - 25

JO - Sustainable Chemistry and Pharmacy

JF - Sustainable Chemistry and Pharmacy

M1 - 100591

ER -

Cyrene: A bio-based sustainable solvent for organic synthesis

Abstract

Keywords

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