Cyclosporin a therapy in paraprotein‐associated neuropathy

John A. Waterston, Martin M. Brown, David A. Ingram, Michael Swash

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A case of IgG paraprotein‐associated demyelinating neuropathy complicated by respiratory failure, which was unresponsive to standard immunosuppressive drug therapy, is reported. Cyclosporin A therapy resulted in a marked clinical recovery with objective improvement in nerve conduction and vital capacity. The beneficial response suggests that cell‐mediated immunity is an important pathogenetic mechanism, and that cyclosporin A may be useful in the treatment of other refractory cases of paraprotein‐associated neuropathy.

Original languageEnglish
Pages (from-to)445-448
Number of pages4
JournalMuscle & Nerve
Issue number4
Publication statusPublished - 1 Jan 1992
Externally publishedYes


  • cyclosporin A
  • neuropathy
  • paraprotein

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