Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450BM3-catalysed hydroxylations

Max J. Cryle; Julia M U Stuthe; Paul R. Ortiz De Montellano; James J. De Voss

Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450BM3-catalysed hydroxylations

Max J. Cryle, Julia M U Stuthe, Paul R. Ortiz De Montellano, James J. De Voss

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Novel cyclopropyl containing fatty acids are good substrates for P450 _BM3 catalysed hydroxylation and analysis of their oxidation products indicates the presence of a radical intermediate (maximum rebound rate 2.6 x 10¹⁰ s^-1) and the absence of any cationic intermediate.

Original language	English
Pages (from-to)	512-513
Number of pages	2
Journal	Chemical Communications
Volume	10
Issue number	5
Publication status	Published - 7 Mar 2004
Externally published	Yes

Cite this

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title = "Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450BM3-catalysed hydroxylations",

abstract = "Novel cyclopropyl containing fatty acids are good substrates for P450 BM3 catalysed hydroxylation and analysis of their oxidation products indicates the presence of a radical intermediate (maximum rebound rate 2.6 x 1010 s-1) and the absence of any cationic intermediate.",

author = "Cryle, {Max J.} and Stuthe, {Julia M U} and {Ortiz De Montellano}, {Paul R.} and {De Voss}, {James J.}",

year = "2004",

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T1 - Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450BM3-catalysed hydroxylations

AU - Cryle, Max J.

AU - Stuthe, Julia M U

AU - Ortiz De Montellano, Paul R.

AU - De Voss, James J.

PY - 2004/3/7

Y1 - 2004/3/7

N2 - Novel cyclopropyl containing fatty acids are good substrates for P450 BM3 catalysed hydroxylation and analysis of their oxidation products indicates the presence of a radical intermediate (maximum rebound rate 2.6 x 1010 s-1) and the absence of any cationic intermediate.

AB - Novel cyclopropyl containing fatty acids are good substrates for P450 BM3 catalysed hydroxylation and analysis of their oxidation products indicates the presence of a radical intermediate (maximum rebound rate 2.6 x 1010 s-1) and the absence of any cationic intermediate.

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M3 - Article

AN - SCOPUS:1642369790

SN - 1359-7345

VL - 10

SP - 512

EP - 513

JO - Chemical Communications

JF - Chemical Communications

IS - 5

ER -

Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450BM3-catalysed hydroxylations

Abstract

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