Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450BM3-catalysed hydroxylations

Max J. Cryle, Julia M U Stuthe, Paul R. Ortiz De Montellano, James J. De Voss

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)


Novel cyclopropyl containing fatty acids are good substrates for P450 BM3 catalysed hydroxylation and analysis of their oxidation products indicates the presence of a radical intermediate (maximum rebound rate 2.6 x 1010 s-1) and the absence of any cationic intermediate.

Original languageEnglish
Pages (from-to)512-513
Number of pages2
JournalChemical Communications
Issue number5
Publication statusPublished - 7 Mar 2004
Externally publishedYes

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