Cyclophilins in Atherosclerosis: A new therapeutic target?

Michael Bukrinsky, Alexander Orekhov, Michael Ditiatkovski, Dmitri Sviridov

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

Abstract

Atherosclerosis is a chronic disease with a significant inflammatory component. Recent studies indicate a role of extracellular cyclophilins as contributors to endothelial inflammation and pathogenesis of atherosclerosis. In this article, we review current literature on pro-inflammatory activities of extracellular cyclophilins and discuss possible approaches to selectively target this novel proinflammatory factor.

Original languageEnglish
Pages (from-to)5904-5908
Number of pages5
JournalCurrent Pharmaceutical Design
Volume19
Issue number33
Publication statusPublished - Oct 2013
Externally publishedYes

Keywords

  • CD147
  • Chemotaxis
  • Extracellular cyclophilins
  • Inflammation
  • Leukocytes
  • Monocytes

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